(define (problem Pathways-10)
(:domain Pathways-ComplexPreferences)
(:objects
	SP1 - simple
	Skp2 - simple
	Skp1 - simple
	RPA - simple
	Raf1 - simple
	pRbp2 - simple
	pRbp1-E2F4p1-DP12 - simple
	pRb-E2F4p1-DP12 - simple
	Plk1 - simple
	p57p1 - simple
	p57 - simple
	p27 - simple
	p130-E2F5p1-DP12 - simple
	p130-E2F4p1-DP12 - simple
	p130 - simple
	Max - simple
	Jun - simple
	HDAC1-pRbp1-E2F4-DP12 - simple
	HDAC1-pRbp1-E2F13p1-DP12 - simple
	HDAC1-pRbp1-E2F13-DP12 - simple
	HDAC1 - simple
	gp19ARF - simple
	gE2 - simple
	gcdc25A - simple
	E2F6-DP12p1 - simple
	E2F5 - simple
	E2F4-DP12p1 - simple
	E2F4 - simple
	E2F3 - simple
	E2F13p1-DP12 - simple
	E2F13-DP12 - simple
	E2F13 - simple
	E2F1 - simple
	DP12 - simple
	DMP1 - simple
	cdk46p3-cycD - simple
	cdk46p1 - simple
	cdk2p1 - simple
	APC - simple
	cdk2-cycA-E2F13 - complex
	cdk2p1-cycA-E2F13 - complex
	c-Myc-Max-gcdc25A - complex
	c-Myc-Max - complex
	APCp1 - complex
	DMP1-cycD - complex
	DMP1-cycDp1 - complex
	DMP1-gp19ARF - complex
	DMP1p1-cycD - complex
	DMP1p1-cycDp1 - complex
	DMP1p1 - complex
	DMP1p1-gp19ARF - complex
	E2F13-DP12-gE2 - complex
	E2F13p1-DP12-gE2 - complex
	E2F1-DP12 - complex
	E2F3-DP12 - complex
	E2F4-DP12-gE2 - complex
	E2F5-DP12-gE2 - complex
	E2F6-DP12p1-gE2 - complex
	HDAC1-p107-E2F4-DP12-gE2 - complex
	HDAC1-p107-E2F4-DP12 - complex
	HDAC1-p107-E2F4-DP12p1 - complex
	HDAC1-p130-E2F4-DP12-gE2 - complex
	HDAC1-p130-E2F4-DP12 - complex
	HDAC1-p130-E2F4-DP12p1 - complex
	HDAC1-p130-E2F5-DP12-gE2 - complex
	HDAC1-p130-E2F5-DP12 - complex
	HDAC1-pRb-E2F4p1-DP12 - complex
	HDAC1-pRbp1-E2F13-DP12-gE2 - complex
	HDAC1-pRbp1-E2F13p1-DP12-gE2 - complex
	HDAC1-pRbp1-E2F4-DP12-gE2 - complex
	p107-E2F4-DP12-gE2 - complex
	p107-E2F4-DP12 - complex
	p107-E2F4-DP12p1-gE2 - complex
	p107-E2F4-DP12p1 - complex
	p130-E2F4-DP12-gE2 - complex
	p130-E2F4-DP12p1-gE2 - complex
	p130-E2F4-DP12p1 - complex
	p130-E2F5-DP12-gE2 - complex
	E2F5-DP12 - complex
	cdk46 - complex
	p27-cdk2-cycA - complex
	p27-cdk2-cycEp1 - complex
	p27-cdk2-cycE - complex
	p27-cdk2p1-cycA - complex
	p27-cdk2p1-cycEp1 - complex
	p27-cdk2p1-cycE - complex
	p27-cdk46-cycDp1 - complex
	p27-cdk46-cycD - complex
	p27-cdk46p1-cycDp1 - complex
	p27-cdk46p1-cycD - complex
	p57-cdk2-cycA - complex
	p57-cdk2-cycEp1 - complex
	p57-cdk2-cycE - complex
	p57-cdk2p1-cycA - complex
	p57-cdk2p1-cycEp1 - complex
	p57-cdk2p1-cycE - complex
	p57-cdk46-cycDp1 - complex
	p57-cdk46-cycD - complex
	p57-cdk46p1-cycDp1 - complex
	p57-cdk46p1-cycD - complex
	p57p1-cdk46-cycDp1 - complex
	p57p1-cdk46-cycD - complex
	p57p1-cdk46p1-cycDp1 - complex
	p57p1-cdk46p1-cycD - complex
	cdk2-cycEp1 - complex
	cdk2-cycE - complex
	cdk2p1-cycEp1 - complex
	cdk2p1-cycE - complex
	cdk46-cycDp1 - complex
	cdk46-cycD - complex
	cdk46p1-cycDp1 - complex
	cdk46p1-cycD - complex
	pRb-E2F4p1-DP12-gE2 - complex
	E2F4-DP12 - complex
	pRbp1-E2F4p1-DP12-gE2 - complex
	pRbp1p2-Jun - complex
	pRbp1p2 - complex
	pRbp2-Jun - complex
	Raf1-cdc25Ap1 - complex
	cdc25Ap1 - complex
	Raf1-cdc25A - complex
	cdc25A - complex
	Raf1-p130-E2F4-DP12-gE2 - complex
	Raf1-p130-E2F4-DP12 - complex
	p130-E2F4-DP12 - complex
	Raf1-p130-E2F4p1-DP12-gE2 - complex
	Raf1-p130-E2F4p1-DP12 - complex
	Raf1-p130-E2F5-DP12-gE2 - complex
	Raf1-p130-E2F5-DP12 - complex
	p130-E2F5-DP12 - complex
	Raf1-p130-E2F5p1-DP12-gE2 - complex
	Raf1-p130-E2F5p1-DP12 - complex
	Raf1-pRb-E2F4p1-DP12-gE2 - complex
	Raf1-pRb-E2F4p1-DP12 - complex
	Raf1-pRbp1-E2F4p1-DP12-gE2 - complex
	Raf1-pRbp1-E2F4p1-DP12 - complex
	RPA-cycA - complex
	Skp2-cdk2-cycA - complex
	Skp2-cdk2p1-cycA - complex
	Skp2-Skp1-cdk2-cycA - complex
	Skp2-Skp1-cdk2p1-cycA - complex
	cdk2-cycA - complex
	cdk2p1-cycA - complex
	Skp2-Skp1 - complex
	SP1-E2F13 - complex
	c-Myc - complex
	cycA - complex
	cycD - complex
	cycDp1 - complex
	cycE - complex
	cycEp1 - complex
	p19ARF - complex
	pol - complex
	SP1-p107p1 - complex
	p107p1 - complex
	SP1-p107 - complex
	p107 - complex)


(:init
	(possible SP1)
	(= (available SP1) 0)
	(possible Skp2)
	(= (available Skp2) 0)
	(possible Skp1)
	(= (available Skp1) 0)
	(possible RPA)
	(= (available RPA) 0)
	(possible Raf1)
	(= (available Raf1) 0)
	(possible pRbp2)
	(= (available pRbp2) 0)
	(possible pRbp1-E2F4p1-DP12)
	(= (available pRbp1-E2F4p1-DP12) 0)
	(possible pRb-E2F4p1-DP12)
	(= (available pRb-E2F4p1-DP12) 0)
	(possible Plk1)
	(= (available Plk1) 0)
	(possible p57p1)
	(= (available p57p1) 0)
	(possible p57)
	(= (available p57) 0)
	(possible p27)
	(= (available p27) 0)
	(possible p130-E2F5p1-DP12)
	(= (available p130-E2F5p1-DP12) 0)
	(possible p130-E2F4p1-DP12)
	(= (available p130-E2F4p1-DP12) 0)
	(possible p130)
	(= (available p130) 0)
	(possible Max)
	(= (available Max) 0)
	(possible Jun)
	(= (available Jun) 0)
	(possible HDAC1-pRbp1-E2F4-DP12)
	(= (available HDAC1-pRbp1-E2F4-DP12) 0)
	(possible HDAC1-pRbp1-E2F13p1-DP12)
	(= (available HDAC1-pRbp1-E2F13p1-DP12) 0)
	(possible HDAC1-pRbp1-E2F13-DP12)
	(= (available HDAC1-pRbp1-E2F13-DP12) 0)
	(possible HDAC1)
	(= (available HDAC1) 0)
	(possible gp19ARF)
	(= (available gp19ARF) 0)
	(possible gE2)
	(= (available gE2) 0)
	(possible gcdc25A)
	(= (available gcdc25A) 0)
	(possible E2F6-DP12p1)
	(= (available E2F6-DP12p1) 0)
	(possible E2F5)
	(= (available E2F5) 0)
	(possible E2F4-DP12p1)
	(= (available E2F4-DP12p1) 0)
	(possible E2F4)
	(= (available E2F4) 0)
	(possible E2F3)
	(= (available E2F3) 0)
	(possible E2F13p1-DP12)
	(= (available E2F13p1-DP12) 0)
	(possible E2F13-DP12)
	(= (available E2F13-DP12) 0)
	(possible E2F13)
	(= (available E2F13) 0)
	(possible E2F1)
	(= (available E2F1) 0)
	(possible DP12)
	(= (available DP12) 0)
	(possible DMP1)
	(= (available DMP1) 0)
	(possible cdk46p3-cycD)
	(= (available cdk46p3-cycD) 0)
	(possible cdk46p1)
	(= (available cdk46p1) 0)
	(possible cdk2p1)
	(= (available cdk2p1) 0)
	(possible APC)
	(= (available APC) 0)
	(= (available cdk2-cycA-E2F13) 0)
	(= (available cdk2p1-cycA-E2F13) 0)
	(= (available c-Myc-Max-gcdc25A) 0)
	(= (available c-Myc-Max) 0)
	(= (available APCp1) 0)
	(= (available DMP1-cycD) 0)
	(= (available DMP1-cycDp1) 0)
	(= (available DMP1-gp19ARF) 0)
	(= (available DMP1p1-cycD) 0)
	(= (available DMP1p1-cycDp1) 0)
	(= (available DMP1p1) 0)
	(= (available DMP1p1-gp19ARF) 0)
	(= (available E2F13-DP12-gE2) 0)
	(= (available E2F13p1-DP12-gE2) 0)
	(= (available E2F1-DP12) 0)
	(= (available E2F3-DP12) 0)
	(= (available E2F4-DP12-gE2) 0)
	(= (available E2F5-DP12-gE2) 0)
	(= (available E2F6-DP12p1-gE2) 0)
	(= (available HDAC1-p107-E2F4-DP12-gE2) 0)
	(= (available HDAC1-p107-E2F4-DP12) 0)
	(= (available HDAC1-p107-E2F4-DP12p1) 0)
	(= (available HDAC1-p130-E2F4-DP12-gE2) 0)
	(= (available HDAC1-p130-E2F4-DP12) 0)
	(= (available HDAC1-p130-E2F4-DP12p1) 0)
	(= (available HDAC1-p130-E2F5-DP12-gE2) 0)
	(= (available HDAC1-p130-E2F5-DP12) 0)
	(= (available HDAC1-pRb-E2F4p1-DP12) 0)
	(= (available HDAC1-pRbp1-E2F13-DP12-gE2) 0)
	(= (available HDAC1-pRbp1-E2F13p1-DP12-gE2) 0)
	(= (available HDAC1-pRbp1-E2F4-DP12-gE2) 0)
	(= (available p107-E2F4-DP12-gE2) 0)
	(= (available p107-E2F4-DP12) 0)
	(= (available p107-E2F4-DP12p1-gE2) 0)
	(= (available p107-E2F4-DP12p1) 0)
	(= (available p130-E2F4-DP12-gE2) 0)
	(= (available p130-E2F4-DP12p1-gE2) 0)
	(= (available p130-E2F4-DP12p1) 0)
	(= (available p130-E2F5-DP12-gE2) 0)
	(= (available E2F5-DP12) 0)
	(= (available cdk46) 0)
	(= (available p27-cdk2-cycA) 0)
	(= (available p27-cdk2-cycEp1) 0)
	(= (available p27-cdk2-cycE) 0)
	(= (available p27-cdk2p1-cycA) 0)
	(= (available p27-cdk2p1-cycEp1) 0)
	(= (available p27-cdk2p1-cycE) 0)
	(= (available p27-cdk46-cycDp1) 0)
	(= (available p27-cdk46-cycD) 0)
	(= (available p27-cdk46p1-cycDp1) 0)
	(= (available p27-cdk46p1-cycD) 0)
	(= (available p57-cdk2-cycA) 0)
	(= (available p57-cdk2-cycEp1) 0)
	(= (available p57-cdk2-cycE) 0)
	(= (available p57-cdk2p1-cycA) 0)
	(= (available p57-cdk2p1-cycEp1) 0)
	(= (available p57-cdk2p1-cycE) 0)
	(= (available p57-cdk46-cycDp1) 0)
	(= (available p57-cdk46-cycD) 0)
	(= (available p57-cdk46p1-cycDp1) 0)
	(= (available p57-cdk46p1-cycD) 0)
	(= (available p57p1-cdk46-cycDp1) 0)
	(= (available p57p1-cdk46-cycD) 0)
	(= (available p57p1-cdk46p1-cycDp1) 0)
	(= (available p57p1-cdk46p1-cycD) 0)
	(= (available cdk2-cycEp1) 0)
	(= (available cdk2-cycE) 0)
	(= (available cdk2p1-cycEp1) 0)
	(= (available cdk2p1-cycE) 0)
	(= (available cdk46-cycDp1) 0)
	(= (available cdk46-cycD) 0)
	(= (available cdk46p1-cycDp1) 0)
	(= (available cdk46p1-cycD) 0)
	(= (available pRb-E2F4p1-DP12-gE2) 0)
	(= (available E2F4-DP12) 0)
	(= (available pRbp1-E2F4p1-DP12-gE2) 0)
	(= (available pRbp1p2-Jun) 0)
	(= (available pRbp1p2) 0)
	(= (available pRbp2-Jun) 0)
	(= (available Raf1-cdc25Ap1) 0)
	(= (available cdc25Ap1) 0)
	(= (available Raf1-cdc25A) 0)
	(= (available cdc25A) 0)
	(= (available Raf1-p130-E2F4-DP12-gE2) 0)
	(= (available Raf1-p130-E2F4-DP12) 0)
	(= (available p130-E2F4-DP12) 0)
	(= (available Raf1-p130-E2F4p1-DP12-gE2) 0)
	(= (available Raf1-p130-E2F4p1-DP12) 0)
	(= (available Raf1-p130-E2F5-DP12-gE2) 0)
	(= (available Raf1-p130-E2F5-DP12) 0)
	(= (available p130-E2F5-DP12) 0)
	(= (available Raf1-p130-E2F5p1-DP12-gE2) 0)
	(= (available Raf1-p130-E2F5p1-DP12) 0)
	(= (available Raf1-pRb-E2F4p1-DP12-gE2) 0)
	(= (available Raf1-pRb-E2F4p1-DP12) 0)
	(= (available Raf1-pRbp1-E2F4p1-DP12-gE2) 0)
	(= (available Raf1-pRbp1-E2F4p1-DP12) 0)
	(= (available RPA-cycA) 0)
	(= (available Skp2-cdk2-cycA) 0)
	(= (available Skp2-cdk2p1-cycA) 0)
	(= (available Skp2-Skp1-cdk2-cycA) 0)
	(= (available Skp2-Skp1-cdk2p1-cycA) 0)
	(= (available cdk2-cycA) 0)
	(= (available cdk2p1-cycA) 0)
	(= (available Skp2-Skp1) 0)
	(= (available SP1-E2F13) 0)
	(= (available c-Myc) 0)
	(= (available cycA) 0)
	(= (available cycD) 0)
	(= (available cycDp1) 0)
	(= (available cycE) 0)
	(= (available cycEp1) 0)
	(= (available p19ARF) 0)
	(= (available pol) 0)
	(= (available SP1-p107p1) 0)
	(= (available p107p1) 0)
	(= (available SP1-p107) 0)
	(= (available p107) 0)
	(catalyzed-association-reaction APC Plk1 APCp1)
	(= (need-for-catalyzed-association APC Plk1 APCp1) 3)
	(= (need-for-catalyzed-association Plk1 APC APCp1) 3)
	(= (prod-by-catalyzed-association APC Plk1 APCp1) 1)
	(catalyzed-association-reaction cdc25A Raf1 cdc25Ap1)
	(= (need-for-catalyzed-association cdc25A Raf1 cdc25Ap1) 2)
	(= (need-for-catalyzed-association Raf1 cdc25A cdc25Ap1) 4)
	(= (prod-by-catalyzed-association cdc25A Raf1 cdc25Ap1) 1)
	(association-reaction cdk2-cycA E2F13 cdk2-cycA-E2F13)
	(= (need-for-association cdk2-cycA E2F13 cdk2-cycA-E2F13) 1)
	(= (need-for-association E2F13 cdk2-cycA cdk2-cycA-E2F13) 3)
	(= (prod-by-association cdk2-cycA E2F13 cdk2-cycA-E2F13) 4)
	(catalyzed-association-reaction cdk2p1-cycA cdc25Ap1 cdk2-cycA)
	(= (need-for-catalyzed-association cdk2p1-cycA cdc25Ap1 cdk2-cycA) 1)
	(= (need-for-catalyzed-association cdc25Ap1 cdk2p1-cycA cdk2-cycA) 3)
	(= (prod-by-catalyzed-association cdk2p1-cycA cdc25Ap1 cdk2-cycA) 1)
	(association-reaction cdk2p1 cycA cdk2p1-cycA)
	(= (need-for-association cdk2p1 cycA cdk2p1-cycA) 2)
	(= (need-for-association cycA cdk2p1 cdk2p1-cycA) 3)
	(= (prod-by-association cdk2p1 cycA cdk2p1-cycA) 3)
	(association-reaction cdk2p1-cycA E2F13 cdk2p1-cycA-E2F13)
	(= (need-for-association cdk2p1-cycA E2F13 cdk2p1-cycA-E2F13) 3)
	(= (need-for-association E2F13 cdk2p1-cycA cdk2p1-cycA-E2F13) 2)
	(= (prod-by-association cdk2p1-cycA E2F13 cdk2p1-cycA-E2F13) 4)
	(catalyzed-association-reaction cdk2p1-cycE cdc25Ap1 cdk2-cycE)
	(= (need-for-catalyzed-association cdk2p1-cycE cdc25Ap1 cdk2-cycE) 4)
	(= (need-for-catalyzed-association cdc25Ap1 cdk2p1-cycE cdk2-cycE) 4)
	(= (prod-by-catalyzed-association cdk2p1-cycE cdc25Ap1 cdk2-cycE) 2)
	(association-reaction cdk2p1 cycE cdk2p1-cycE)
	(= (need-for-association cdk2p1 cycE cdk2p1-cycE) 4)
	(= (need-for-association cycE cdk2p1 cdk2p1-cycE) 1)
	(= (prod-by-association cdk2p1 cycE cdk2p1-cycE) 2)
	(catalyzed-association-reaction cdk2p1-cycEp1 cdc25Ap1 cdk2-cycEp1)
	(= (need-for-catalyzed-association cdk2p1-cycEp1 cdc25Ap1 cdk2-cycEp1) 1)
	(= (need-for-catalyzed-association cdc25Ap1 cdk2p1-cycEp1 cdk2-cycEp1) 4)
	(= (prod-by-catalyzed-association cdk2p1-cycEp1 cdc25Ap1 cdk2-cycEp1) 3)
	(association-reaction cdk2p1 cycEp1 cdk2p1-cycEp1)
	(= (need-for-association cdk2p1 cycEp1 cdk2p1-cycEp1) 4)
	(= (need-for-association cycEp1 cdk2p1 cdk2p1-cycEp1) 2)
	(= (prod-by-association cdk2p1 cycEp1 cdk2p1-cycEp1) 3)
	(association-reaction cdk46 cycD cdk46-cycD)
	(= (need-for-association cdk46 cycD cdk46-cycD) 4)
	(= (need-for-association cycD cdk46 cdk46-cycD) 4)
	(= (prod-by-association cdk46 cycD cdk46-cycD) 1)
	(association-reaction cdk46 cycDp1 cdk46-cycDp1)
	(= (need-for-association cdk46 cycDp1 cdk46-cycDp1) 4)
	(= (need-for-association cycDp1 cdk46 cdk46-cycDp1) 2)
	(= (prod-by-association cdk46 cycDp1 cdk46-cycDp1) 4)
	(catalyzed-association-reaction cdk46p1 cdc25Ap1 cdk46)
	(= (need-for-catalyzed-association cdk46p1 cdc25Ap1 cdk46) 4)
	(= (need-for-catalyzed-association cdc25Ap1 cdk46p1 cdk46) 2)
	(= (prod-by-catalyzed-association cdk46p1 cdc25Ap1 cdk46) 2)
	(association-reaction cdk46p1 cycD cdk46p1-cycD)
	(= (need-for-association cdk46p1 cycD cdk46p1-cycD) 3)
	(= (need-for-association cycD cdk46p1 cdk46p1-cycD) 2)
	(= (prod-by-association cdk46p1 cycD cdk46p1-cycD) 4)
	(association-reaction cdk46p1 cycDp1 cdk46p1-cycDp1)
	(= (need-for-association cdk46p1 cycDp1 cdk46p1-cycDp1) 3)
	(= (need-for-association cycDp1 cdk46p1 cdk46p1-cycDp1) 3)
	(= (prod-by-association cdk46p1 cycDp1 cdk46p1-cycDp1) 2)
	(association-reaction c-Myc Max c-Myc-Max)
	(= (need-for-association c-Myc Max c-Myc-Max) 1)
	(= (need-for-association Max c-Myc c-Myc-Max) 2)
	(= (prod-by-association c-Myc Max c-Myc-Max) 4)
	(synthesis-reaction c-Myc-Max-gcdc25A cdc25A) 
	(= (need-for-synthesis c-Myc-Max-gcdc25A cdc25A) 1)
	(= (prod-by-synthesis c-Myc-Max-gcdc25A cdc25A) 1)
	(association-reaction c-Myc-Max gcdc25A c-Myc-Max-gcdc25A)
	(= (need-for-association c-Myc-Max gcdc25A c-Myc-Max-gcdc25A) 3)
	(= (need-for-association gcdc25A c-Myc-Max c-Myc-Max-gcdc25A) 2)
	(= (prod-by-association c-Myc-Max gcdc25A c-Myc-Max-gcdc25A) 1)
	(catalyzed-association-reaction cycA Skp2-Skp1 Skp2-Skp1)
	(= (need-for-catalyzed-association cycA Skp2-Skp1 Skp2-Skp1) 4)
	(= (need-for-catalyzed-association Skp2-Skp1 cycA Skp2-Skp1) 4)
	(= (prod-by-catalyzed-association cycA Skp2-Skp1 Skp2-Skp1) 1)
	(catalyzed-association-reaction DMP1 cdk46p3-cycD DMP1p1)
	(= (need-for-catalyzed-association DMP1 cdk46p3-cycD DMP1p1) 3)
	(= (need-for-catalyzed-association cdk46p3-cycD DMP1 DMP1p1) 2)
	(= (prod-by-catalyzed-association DMP1 cdk46p3-cycD DMP1p1) 4)
	(association-reaction DMP1 cycD DMP1-cycD)
	(= (need-for-association DMP1 cycD DMP1-cycD) 4)
	(= (need-for-association cycD DMP1 DMP1-cycD) 4)
	(= (prod-by-association DMP1 cycD DMP1-cycD) 4)
	(association-reaction DMP1 cycDp1 DMP1-cycDp1)
	(= (need-for-association DMP1 cycDp1 DMP1-cycDp1) 4)
	(= (need-for-association cycDp1 DMP1 DMP1-cycDp1) 4)
	(= (prod-by-association DMP1 cycDp1 DMP1-cycDp1) 3)
	(association-reaction DMP1 gp19ARF DMP1-gp19ARF)
	(= (need-for-association DMP1 gp19ARF DMP1-gp19ARF) 1)
	(= (need-for-association gp19ARF DMP1 DMP1-gp19ARF) 3)
	(= (prod-by-association DMP1 gp19ARF DMP1-gp19ARF) 3)
	(association-reaction DMP1p1 cycD DMP1p1-cycD)
	(= (need-for-association DMP1p1 cycD DMP1p1-cycD) 2)
	(= (need-for-association cycD DMP1p1 DMP1p1-cycD) 4)
	(= (prod-by-association DMP1p1 cycD DMP1p1-cycD) 1)
	(association-reaction DMP1p1 cycDp1 DMP1p1-cycDp1)
	(= (need-for-association DMP1p1 cycDp1 DMP1p1-cycDp1) 3)
	(= (need-for-association cycDp1 DMP1p1 DMP1p1-cycDp1) 3)
	(= (prod-by-association DMP1p1 cycDp1 DMP1p1-cycDp1) 4)
	(association-reaction DMP1p1 gp19ARF DMP1p1-gp19ARF)
	(= (need-for-association DMP1p1 gp19ARF DMP1p1-gp19ARF) 2)
	(= (need-for-association gp19ARF DMP1p1 DMP1p1-gp19ARF) 1)
	(= (prod-by-association DMP1p1 gp19ARF DMP1p1-gp19ARF) 4)
	(synthesis-reaction DMP1p1-gp19ARF p19ARF) 
	(= (need-for-synthesis DMP1p1-gp19ARF p19ARF) 3)
	(= (prod-by-synthesis DMP1p1-gp19ARF p19ARF) 4)
	(synthesis-reaction E2F13-DP12-gE2 c-Myc) 
	(= (need-for-synthesis E2F13-DP12-gE2 c-Myc) 4)
	(= (prod-by-synthesis E2F13-DP12-gE2 c-Myc) 3)
	(synthesis-reaction E2F13-DP12-gE2 cycA) 
	(= (need-for-synthesis E2F13-DP12-gE2 cycA) 2)
	(= (prod-by-synthesis E2F13-DP12-gE2 cycA) 2)
	(synthesis-reaction E2F13-DP12-gE2 cycD) 
	(= (need-for-synthesis E2F13-DP12-gE2 cycD) 3)
	(= (prod-by-synthesis E2F13-DP12-gE2 cycD) 1)
	(synthesis-reaction E2F13-DP12-gE2 cycDp1) 
	(= (need-for-synthesis E2F13-DP12-gE2 cycDp1) 1)
	(= (prod-by-synthesis E2F13-DP12-gE2 cycDp1) 4)
	(synthesis-reaction E2F13-DP12-gE2 cycE) 
	(= (need-for-synthesis E2F13-DP12-gE2 cycE) 3)
	(= (prod-by-synthesis E2F13-DP12-gE2 cycE) 2)
	(synthesis-reaction E2F13-DP12-gE2 cycEp1) 
	(= (need-for-synthesis E2F13-DP12-gE2 cycEp1) 3)
	(= (prod-by-synthesis E2F13-DP12-gE2 cycEp1) 3)
	(association-reaction E2F13-DP12 gE2 E2F13-DP12-gE2)
	(= (need-for-association E2F13-DP12 gE2 E2F13-DP12-gE2) 1)
	(= (need-for-association gE2 E2F13-DP12 E2F13-DP12-gE2) 2)
	(= (prod-by-association E2F13-DP12 gE2 E2F13-DP12-gE2) 2)
	(synthesis-reaction E2F13-DP12-gE2 p107) 
	(= (need-for-synthesis E2F13-DP12-gE2 p107) 4)
	(= (prod-by-synthesis E2F13-DP12-gE2 p107) 1)
	(synthesis-reaction E2F13-DP12-gE2 p107p1) 
	(= (need-for-synthesis E2F13-DP12-gE2 p107p1) 2)
	(= (prod-by-synthesis E2F13-DP12-gE2 p107p1) 2)
	(synthesis-reaction E2F13-DP12-gE2 p19ARF) 
	(= (need-for-synthesis E2F13-DP12-gE2 p19ARF) 3)
	(= (prod-by-synthesis E2F13-DP12-gE2 p19ARF) 3)
	(synthesis-reaction E2F13-DP12-gE2 pol) 
	(= (need-for-synthesis E2F13-DP12-gE2 pol) 1)
	(= (prod-by-synthesis E2F13-DP12-gE2 pol) 3)
	(synthesis-reaction E2F13p1-DP12-gE2 c-Myc) 
	(= (need-for-synthesis E2F13p1-DP12-gE2 c-Myc) 1)
	(= (prod-by-synthesis E2F13p1-DP12-gE2 c-Myc) 3)
	(synthesis-reaction E2F13p1-DP12-gE2 cycA) 
	(= (need-for-synthesis E2F13p1-DP12-gE2 cycA) 2)
	(= (prod-by-synthesis E2F13p1-DP12-gE2 cycA) 2)
	(synthesis-reaction E2F13p1-DP12-gE2 cycD) 
	(= (need-for-synthesis E2F13p1-DP12-gE2 cycD) 3)
	(= (prod-by-synthesis E2F13p1-DP12-gE2 cycD) 2)
	(synthesis-reaction E2F13p1-DP12-gE2 cycDp1) 
	(= (need-for-synthesis E2F13p1-DP12-gE2 cycDp1) 4)
	(= (prod-by-synthesis E2F13p1-DP12-gE2 cycDp1) 2)
	(synthesis-reaction E2F13p1-DP12-gE2 cycE) 
	(= (need-for-synthesis E2F13p1-DP12-gE2 cycE) 1)
	(= (prod-by-synthesis E2F13p1-DP12-gE2 cycE) 3)
	(synthesis-reaction E2F13p1-DP12-gE2 cycEp1) 
	(= (need-for-synthesis E2F13p1-DP12-gE2 cycEp1) 4)
	(= (prod-by-synthesis E2F13p1-DP12-gE2 cycEp1) 2)
	(association-reaction E2F13p1-DP12 gE2 E2F13p1-DP12-gE2)
	(= (need-for-association E2F13p1-DP12 gE2 E2F13p1-DP12-gE2) 1)
	(= (need-for-association gE2 E2F13p1-DP12 E2F13p1-DP12-gE2) 4)
	(= (prod-by-association E2F13p1-DP12 gE2 E2F13p1-DP12-gE2) 2)
	(synthesis-reaction E2F13p1-DP12-gE2 p107) 
	(= (need-for-synthesis E2F13p1-DP12-gE2 p107) 4)
	(= (prod-by-synthesis E2F13p1-DP12-gE2 p107) 3)
	(synthesis-reaction E2F13p1-DP12-gE2 p107p1) 
	(= (need-for-synthesis E2F13p1-DP12-gE2 p107p1) 3)
	(= (prod-by-synthesis E2F13p1-DP12-gE2 p107p1) 3)
	(synthesis-reaction E2F13p1-DP12-gE2 p19ARF) 
	(= (need-for-synthesis E2F13p1-DP12-gE2 p19ARF) 1)
	(= (prod-by-synthesis E2F13p1-DP12-gE2 p19ARF) 3)
	(synthesis-reaction E2F13p1-DP12-gE2 pol) 
	(= (need-for-synthesis E2F13p1-DP12-gE2 pol) 4)
	(= (prod-by-synthesis E2F13p1-DP12-gE2 pol) 2)
	(association-reaction E2F1 DP12 E2F1-DP12)
	(= (need-for-association E2F1 DP12 E2F1-DP12) 2)
	(= (need-for-association DP12 E2F1 E2F1-DP12) 4)
	(= (prod-by-association E2F1 DP12 E2F1-DP12) 3)
	(association-reaction E2F3 DP12 E2F3-DP12)
	(= (need-for-association E2F3 DP12 E2F3-DP12) 3)
	(= (need-for-association DP12 E2F3 E2F3-DP12) 2)
	(= (prod-by-association E2F3 DP12 E2F3-DP12) 1)
	(association-reaction E2F4 DP12 E2F4-DP12)
	(= (need-for-association E2F4 DP12 E2F4-DP12) 3)
	(= (need-for-association DP12 E2F4 E2F4-DP12) 1)
	(= (prod-by-association E2F4 DP12 E2F4-DP12) 1)
	(synthesis-reaction E2F4-DP12-gE2 c-Myc) 
	(= (need-for-synthesis E2F4-DP12-gE2 c-Myc) 2)
	(= (prod-by-synthesis E2F4-DP12-gE2 c-Myc) 2)
	(synthesis-reaction E2F4-DP12-gE2 cycA) 
	(= (need-for-synthesis E2F4-DP12-gE2 cycA) 3)
	(= (prod-by-synthesis E2F4-DP12-gE2 cycA) 4)
	(synthesis-reaction E2F4-DP12-gE2 cycD) 
	(= (need-for-synthesis E2F4-DP12-gE2 cycD) 3)
	(= (prod-by-synthesis E2F4-DP12-gE2 cycD) 2)
	(synthesis-reaction E2F4-DP12-gE2 cycDp1) 
	(= (need-for-synthesis E2F4-DP12-gE2 cycDp1) 2)
	(= (prod-by-synthesis E2F4-DP12-gE2 cycDp1) 4)
	(synthesis-reaction E2F4-DP12-gE2 cycE) 
	(= (need-for-synthesis E2F4-DP12-gE2 cycE) 4)
	(= (prod-by-synthesis E2F4-DP12-gE2 cycE) 1)
	(synthesis-reaction E2F4-DP12-gE2 cycEp1) 
	(= (need-for-synthesis E2F4-DP12-gE2 cycEp1) 1)
	(= (prod-by-synthesis E2F4-DP12-gE2 cycEp1) 1)
	(association-reaction E2F4-DP12 gE2 E2F4-DP12-gE2)
	(= (need-for-association E2F4-DP12 gE2 E2F4-DP12-gE2) 4)
	(= (need-for-association gE2 E2F4-DP12 E2F4-DP12-gE2) 3)
	(= (prod-by-association E2F4-DP12 gE2 E2F4-DP12-gE2) 4)
	(synthesis-reaction E2F4-DP12-gE2 p107) 
	(= (need-for-synthesis E2F4-DP12-gE2 p107) 2)
	(= (prod-by-synthesis E2F4-DP12-gE2 p107) 1)
	(synthesis-reaction E2F4-DP12-gE2 p107p1) 
	(= (need-for-synthesis E2F4-DP12-gE2 p107p1) 2)
	(= (prod-by-synthesis E2F4-DP12-gE2 p107p1) 2)
	(synthesis-reaction E2F4-DP12-gE2 p19ARF) 
	(= (need-for-synthesis E2F4-DP12-gE2 p19ARF) 4)
	(= (prod-by-synthesis E2F4-DP12-gE2 p19ARF) 2)
	(synthesis-reaction E2F4-DP12-gE2 pol) 
	(= (need-for-synthesis E2F4-DP12-gE2 pol) 3)
	(= (prod-by-synthesis E2F4-DP12-gE2 pol) 1)
	(association-reaction E2F5 DP12 E2F5-DP12)
	(= (need-for-association E2F5 DP12 E2F5-DP12) 1)
	(= (need-for-association DP12 E2F5 E2F5-DP12) 1)
	(= (prod-by-association E2F5 DP12 E2F5-DP12) 4)
	(synthesis-reaction E2F5-DP12-gE2 c-Myc) 
	(= (need-for-synthesis E2F5-DP12-gE2 c-Myc) 3)
	(= (prod-by-synthesis E2F5-DP12-gE2 c-Myc) 1)
	(synthesis-reaction E2F5-DP12-gE2 cycA) 
	(= (need-for-synthesis E2F5-DP12-gE2 cycA) 2)
	(= (prod-by-synthesis E2F5-DP12-gE2 cycA) 3)
	(synthesis-reaction E2F5-DP12-gE2 cycD) 
	(= (need-for-synthesis E2F5-DP12-gE2 cycD) 2)
	(= (prod-by-synthesis E2F5-DP12-gE2 cycD) 3)
	(synthesis-reaction E2F5-DP12-gE2 cycDp1) 
	(= (need-for-synthesis E2F5-DP12-gE2 cycDp1) 4)
	(= (prod-by-synthesis E2F5-DP12-gE2 cycDp1) 4)
	(synthesis-reaction E2F5-DP12-gE2 cycE) 
	(= (need-for-synthesis E2F5-DP12-gE2 cycE) 3)
	(= (prod-by-synthesis E2F5-DP12-gE2 cycE) 3)
	(synthesis-reaction E2F5-DP12-gE2 cycEp1) 
	(= (need-for-synthesis E2F5-DP12-gE2 cycEp1) 1)
	(= (prod-by-synthesis E2F5-DP12-gE2 cycEp1) 4)
	(association-reaction E2F5-DP12 gE2 E2F5-DP12-gE2)
	(= (need-for-association E2F5-DP12 gE2 E2F5-DP12-gE2) 2)
	(= (need-for-association gE2 E2F5-DP12 E2F5-DP12-gE2) 1)
	(= (prod-by-association E2F5-DP12 gE2 E2F5-DP12-gE2) 4)
	(synthesis-reaction E2F5-DP12-gE2 p107) 
	(= (need-for-synthesis E2F5-DP12-gE2 p107) 2)
	(= (prod-by-synthesis E2F5-DP12-gE2 p107) 1)
	(synthesis-reaction E2F5-DP12-gE2 p107p1) 
	(= (need-for-synthesis E2F5-DP12-gE2 p107p1) 3)
	(= (prod-by-synthesis E2F5-DP12-gE2 p107p1) 4)
	(synthesis-reaction E2F5-DP12-gE2 p19ARF) 
	(= (need-for-synthesis E2F5-DP12-gE2 p19ARF) 4)
	(= (prod-by-synthesis E2F5-DP12-gE2 p19ARF) 1)
	(synthesis-reaction E2F5-DP12-gE2 pol) 
	(= (need-for-synthesis E2F5-DP12-gE2 pol) 1)
	(= (prod-by-synthesis E2F5-DP12-gE2 pol) 2)
	(association-reaction E2F6-DP12p1 gE2 E2F6-DP12p1-gE2)
	(= (need-for-association E2F6-DP12p1 gE2 E2F6-DP12p1-gE2) 2)
	(= (need-for-association gE2 E2F6-DP12p1 E2F6-DP12p1-gE2) 4)
	(= (prod-by-association E2F6-DP12p1 gE2 E2F6-DP12p1-gE2) 3)
	(association-reaction HDAC1-p107-E2F4-DP12 gE2 HDAC1-p107-E2F4-DP12-gE2)
	(= (need-for-association HDAC1-p107-E2F4-DP12 gE2 HDAC1-p107-E2F4-DP12-gE2) 1)
	(= (need-for-association gE2 HDAC1-p107-E2F4-DP12 HDAC1-p107-E2F4-DP12-gE2) 4)
	(= (prod-by-association HDAC1-p107-E2F4-DP12 gE2 HDAC1-p107-E2F4-DP12-gE2) 3)
	(association-reaction HDAC1 p107-E2F4-DP12 HDAC1-p107-E2F4-DP12)
	(= (need-for-association HDAC1 p107-E2F4-DP12 HDAC1-p107-E2F4-DP12) 1)
	(= (need-for-association p107-E2F4-DP12 HDAC1 HDAC1-p107-E2F4-DP12) 3)
	(= (prod-by-association HDAC1 p107-E2F4-DP12 HDAC1-p107-E2F4-DP12) 1)
	(association-reaction HDAC1 p107-E2F4-DP12p1 HDAC1-p107-E2F4-DP12p1)
	(= (need-for-association HDAC1 p107-E2F4-DP12p1 HDAC1-p107-E2F4-DP12p1) 2)
	(= (need-for-association p107-E2F4-DP12p1 HDAC1 HDAC1-p107-E2F4-DP12p1) 1)
	(= (prod-by-association HDAC1 p107-E2F4-DP12p1 HDAC1-p107-E2F4-DP12p1) 3)
	(association-reaction HDAC1-p130-E2F4-DP12 gE2 HDAC1-p130-E2F4-DP12-gE2)
	(= (need-for-association HDAC1-p130-E2F4-DP12 gE2 HDAC1-p130-E2F4-DP12-gE2) 3)
	(= (need-for-association gE2 HDAC1-p130-E2F4-DP12 HDAC1-p130-E2F4-DP12-gE2) 3)
	(= (prod-by-association HDAC1-p130-E2F4-DP12 gE2 HDAC1-p130-E2F4-DP12-gE2) 3)
	(association-reaction HDAC1 p130-E2F4-DP12 HDAC1-p130-E2F4-DP12)
	(= (need-for-association HDAC1 p130-E2F4-DP12 HDAC1-p130-E2F4-DP12) 2)
	(= (need-for-association p130-E2F4-DP12 HDAC1 HDAC1-p130-E2F4-DP12) 1)
	(= (prod-by-association HDAC1 p130-E2F4-DP12 HDAC1-p130-E2F4-DP12) 1)
	(association-reaction HDAC1 p130-E2F4-DP12p1 HDAC1-p130-E2F4-DP12p1)
	(= (need-for-association HDAC1 p130-E2F4-DP12p1 HDAC1-p130-E2F4-DP12p1) 2)
	(= (need-for-association p130-E2F4-DP12p1 HDAC1 HDAC1-p130-E2F4-DP12p1) 4)
	(= (prod-by-association HDAC1 p130-E2F4-DP12p1 HDAC1-p130-E2F4-DP12p1) 2)
	(association-reaction HDAC1-p130-E2F5-DP12 gE2 HDAC1-p130-E2F5-DP12-gE2)
	(= (need-for-association HDAC1-p130-E2F5-DP12 gE2 HDAC1-p130-E2F5-DP12-gE2) 2)
	(= (need-for-association gE2 HDAC1-p130-E2F5-DP12 HDAC1-p130-E2F5-DP12-gE2) 3)
	(= (prod-by-association HDAC1-p130-E2F5-DP12 gE2 HDAC1-p130-E2F5-DP12-gE2) 3)
	(association-reaction HDAC1 p130-E2F5-DP12 HDAC1-p130-E2F5-DP12)
	(= (need-for-association HDAC1 p130-E2F5-DP12 HDAC1-p130-E2F5-DP12) 2)
	(= (need-for-association p130-E2F5-DP12 HDAC1 HDAC1-p130-E2F5-DP12) 2)
	(= (prod-by-association HDAC1 p130-E2F5-DP12 HDAC1-p130-E2F5-DP12) 3)
	(association-reaction HDAC1 pRb-E2F4p1-DP12 HDAC1-pRb-E2F4p1-DP12)
	(= (need-for-association HDAC1 pRb-E2F4p1-DP12 HDAC1-pRb-E2F4p1-DP12) 2)
	(= (need-for-association pRb-E2F4p1-DP12 HDAC1 HDAC1-pRb-E2F4p1-DP12) 2)
	(= (prod-by-association HDAC1 pRb-E2F4p1-DP12 HDAC1-pRb-E2F4p1-DP12) 3)
	(association-reaction HDAC1-pRbp1-E2F13-DP12 gE2 HDAC1-pRbp1-E2F13-DP12-gE2)
	(= (need-for-association HDAC1-pRbp1-E2F13-DP12 gE2 HDAC1-pRbp1-E2F13-DP12-gE2) 3)
	(= (need-for-association gE2 HDAC1-pRbp1-E2F13-DP12 HDAC1-pRbp1-E2F13-DP12-gE2) 3)
	(= (prod-by-association HDAC1-pRbp1-E2F13-DP12 gE2 HDAC1-pRbp1-E2F13-DP12-gE2) 2)
	(association-reaction HDAC1-pRbp1-E2F13p1-DP12 gE2 HDAC1-pRbp1-E2F13p1-DP12-gE2)
	(= (need-for-association HDAC1-pRbp1-E2F13p1-DP12 gE2 HDAC1-pRbp1-E2F13p1-DP12-gE2) 1)
	(= (need-for-association gE2 HDAC1-pRbp1-E2F13p1-DP12 HDAC1-pRbp1-E2F13p1-DP12-gE2) 3)
	(= (prod-by-association HDAC1-pRbp1-E2F13p1-DP12 gE2 HDAC1-pRbp1-E2F13p1-DP12-gE2) 1)
	(association-reaction HDAC1-pRbp1-E2F4-DP12 gE2 HDAC1-pRbp1-E2F4-DP12-gE2)
	(= (need-for-association HDAC1-pRbp1-E2F4-DP12 gE2 HDAC1-pRbp1-E2F4-DP12-gE2) 3)
	(= (need-for-association gE2 HDAC1-pRbp1-E2F4-DP12 HDAC1-pRbp1-E2F4-DP12-gE2) 4)
	(= (prod-by-association HDAC1-pRbp1-E2F4-DP12 gE2 HDAC1-pRbp1-E2F4-DP12-gE2) 4)
	(association-reaction p107-E2F4-DP12 gE2 p107-E2F4-DP12-gE2)
	(= (need-for-association p107-E2F4-DP12 gE2 p107-E2F4-DP12-gE2) 4)
	(= (need-for-association gE2 p107-E2F4-DP12 p107-E2F4-DP12-gE2) 1)
	(= (prod-by-association p107-E2F4-DP12 gE2 p107-E2F4-DP12-gE2) 4)
	(association-reaction p107 E2F4-DP12 p107-E2F4-DP12)
	(= (need-for-association p107 E2F4-DP12 p107-E2F4-DP12) 2)
	(= (need-for-association E2F4-DP12 p107 p107-E2F4-DP12) 3)
	(= (prod-by-association p107 E2F4-DP12 p107-E2F4-DP12) 2)
	(association-reaction p107-E2F4-DP12p1 gE2 p107-E2F4-DP12p1-gE2)
	(= (need-for-association p107-E2F4-DP12p1 gE2 p107-E2F4-DP12p1-gE2) 4)
	(= (need-for-association gE2 p107-E2F4-DP12p1 p107-E2F4-DP12p1-gE2) 4)
	(= (prod-by-association p107-E2F4-DP12p1 gE2 p107-E2F4-DP12p1-gE2) 3)
	(association-reaction p107 E2F4-DP12p1 p107-E2F4-DP12p1)
	(= (need-for-association p107 E2F4-DP12p1 p107-E2F4-DP12p1) 4)
	(= (need-for-association E2F4-DP12p1 p107 p107-E2F4-DP12p1) 1)
	(= (prod-by-association p107 E2F4-DP12p1 p107-E2F4-DP12p1) 2)
	(association-reaction p130-E2F4-DP12 gE2 p130-E2F4-DP12-gE2)
	(= (need-for-association p130-E2F4-DP12 gE2 p130-E2F4-DP12-gE2) 1)
	(= (need-for-association gE2 p130-E2F4-DP12 p130-E2F4-DP12-gE2) 3)
	(= (prod-by-association p130-E2F4-DP12 gE2 p130-E2F4-DP12-gE2) 1)
	(association-reaction p130 E2F4-DP12 p130-E2F4-DP12)
	(= (need-for-association p130 E2F4-DP12 p130-E2F4-DP12) 4)
	(= (need-for-association E2F4-DP12 p130 p130-E2F4-DP12) 4)
	(= (prod-by-association p130 E2F4-DP12 p130-E2F4-DP12) 2)
	(association-reaction p130-E2F4-DP12p1 gE2 p130-E2F4-DP12p1-gE2)
	(= (need-for-association p130-E2F4-DP12p1 gE2 p130-E2F4-DP12p1-gE2) 2)
	(= (need-for-association gE2 p130-E2F4-DP12p1 p130-E2F4-DP12p1-gE2) 1)
	(= (prod-by-association p130-E2F4-DP12p1 gE2 p130-E2F4-DP12p1-gE2) 3)
	(association-reaction p130 E2F4-DP12p1 p130-E2F4-DP12p1)
	(= (need-for-association p130 E2F4-DP12p1 p130-E2F4-DP12p1) 4)
	(= (need-for-association E2F4-DP12p1 p130 p130-E2F4-DP12p1) 3)
	(= (prod-by-association p130 E2F4-DP12p1 p130-E2F4-DP12p1) 1)
	(association-reaction p130-E2F5-DP12 gE2 p130-E2F5-DP12-gE2)
	(= (need-for-association p130-E2F5-DP12 gE2 p130-E2F5-DP12-gE2) 1)
	(= (need-for-association gE2 p130-E2F5-DP12 p130-E2F5-DP12-gE2) 3)
	(= (prod-by-association p130-E2F5-DP12 gE2 p130-E2F5-DP12-gE2) 4)
	(association-reaction p130 E2F5-DP12 p130-E2F5-DP12)
	(= (need-for-association p130 E2F5-DP12 p130-E2F5-DP12) 1)
	(= (need-for-association E2F5-DP12 p130 p130-E2F5-DP12) 2)
	(= (prod-by-association p130 E2F5-DP12 p130-E2F5-DP12) 3)
	(association-reaction p27 cdk2-cycA p27-cdk2-cycA)
	(= (need-for-association p27 cdk2-cycA p27-cdk2-cycA) 4)
	(= (need-for-association cdk2-cycA p27 p27-cdk2-cycA) 1)
	(= (prod-by-association p27 cdk2-cycA p27-cdk2-cycA) 3)
	(association-reaction p27 cdk2-cycEp1 p27-cdk2-cycEp1)
	(= (need-for-association p27 cdk2-cycEp1 p27-cdk2-cycEp1) 3)
	(= (need-for-association cdk2-cycEp1 p27 p27-cdk2-cycEp1) 2)
	(= (prod-by-association p27 cdk2-cycEp1 p27-cdk2-cycEp1) 1)
	(association-reaction p27 cdk2-cycE p27-cdk2-cycE)
	(= (need-for-association p27 cdk2-cycE p27-cdk2-cycE) 1)
	(= (need-for-association cdk2-cycE p27 p27-cdk2-cycE) 2)
	(= (prod-by-association p27 cdk2-cycE p27-cdk2-cycE) 4)
	(association-reaction p27 cdk2p1-cycA p27-cdk2p1-cycA)
	(= (need-for-association p27 cdk2p1-cycA p27-cdk2p1-cycA) 3)
	(= (need-for-association cdk2p1-cycA p27 p27-cdk2p1-cycA) 1)
	(= (prod-by-association p27 cdk2p1-cycA p27-cdk2p1-cycA) 4)
	(association-reaction p27 cdk2p1-cycEp1 p27-cdk2p1-cycEp1)
	(= (need-for-association p27 cdk2p1-cycEp1 p27-cdk2p1-cycEp1) 4)
	(= (need-for-association cdk2p1-cycEp1 p27 p27-cdk2p1-cycEp1) 2)
	(= (prod-by-association p27 cdk2p1-cycEp1 p27-cdk2p1-cycEp1) 2)
	(association-reaction p27 cdk2p1-cycE p27-cdk2p1-cycE)
	(= (need-for-association p27 cdk2p1-cycE p27-cdk2p1-cycE) 4)
	(= (need-for-association cdk2p1-cycE p27 p27-cdk2p1-cycE) 1)
	(= (prod-by-association p27 cdk2p1-cycE p27-cdk2p1-cycE) 2)
	(association-reaction p27 cdk46-cycDp1 p27-cdk46-cycDp1)
	(= (need-for-association p27 cdk46-cycDp1 p27-cdk46-cycDp1) 1)
	(= (need-for-association cdk46-cycDp1 p27 p27-cdk46-cycDp1) 2)
	(= (prod-by-association p27 cdk46-cycDp1 p27-cdk46-cycDp1) 2)
	(association-reaction p27 cdk46-cycD p27-cdk46-cycD)
	(= (need-for-association p27 cdk46-cycD p27-cdk46-cycD) 3)
	(= (need-for-association cdk46-cycD p27 p27-cdk46-cycD) 1)
	(= (prod-by-association p27 cdk46-cycD p27-cdk46-cycD) 1)
	(association-reaction p27 cdk46p1-cycDp1 p27-cdk46p1-cycDp1)
	(= (need-for-association p27 cdk46p1-cycDp1 p27-cdk46p1-cycDp1) 4)
	(= (need-for-association cdk46p1-cycDp1 p27 p27-cdk46p1-cycDp1) 1)
	(= (prod-by-association p27 cdk46p1-cycDp1 p27-cdk46p1-cycDp1) 3)
	(association-reaction p27 cdk46p1-cycD p27-cdk46p1-cycD)
	(= (need-for-association p27 cdk46p1-cycD p27-cdk46p1-cycD) 3)
	(= (need-for-association cdk46p1-cycD p27 p27-cdk46p1-cycD) 1)
	(= (prod-by-association p27 cdk46p1-cycD p27-cdk46p1-cycD) 4)
	(association-reaction p57 cdk2-cycA p57-cdk2-cycA)
	(= (need-for-association p57 cdk2-cycA p57-cdk2-cycA) 1)
	(= (need-for-association cdk2-cycA p57 p57-cdk2-cycA) 1)
	(= (prod-by-association p57 cdk2-cycA p57-cdk2-cycA) 4)
	(association-reaction p57 cdk2-cycEp1 p57-cdk2-cycEp1)
	(= (need-for-association p57 cdk2-cycEp1 p57-cdk2-cycEp1) 3)
	(= (need-for-association cdk2-cycEp1 p57 p57-cdk2-cycEp1) 3)
	(= (prod-by-association p57 cdk2-cycEp1 p57-cdk2-cycEp1) 2)
	(association-reaction p57 cdk2-cycE p57-cdk2-cycE)
	(= (need-for-association p57 cdk2-cycE p57-cdk2-cycE) 3)
	(= (need-for-association cdk2-cycE p57 p57-cdk2-cycE) 3)
	(= (prod-by-association p57 cdk2-cycE p57-cdk2-cycE) 3)
	(association-reaction p57 cdk2p1-cycA p57-cdk2p1-cycA)
	(= (need-for-association p57 cdk2p1-cycA p57-cdk2p1-cycA) 2)
	(= (need-for-association cdk2p1-cycA p57 p57-cdk2p1-cycA) 1)
	(= (prod-by-association p57 cdk2p1-cycA p57-cdk2p1-cycA) 3)
	(association-reaction p57 cdk2p1-cycEp1 p57-cdk2p1-cycEp1)
	(= (need-for-association p57 cdk2p1-cycEp1 p57-cdk2p1-cycEp1) 1)
	(= (need-for-association cdk2p1-cycEp1 p57 p57-cdk2p1-cycEp1) 1)
	(= (prod-by-association p57 cdk2p1-cycEp1 p57-cdk2p1-cycEp1) 4)
	(association-reaction p57 cdk2p1-cycE p57-cdk2p1-cycE)
	(= (need-for-association p57 cdk2p1-cycE p57-cdk2p1-cycE) 3)
	(= (need-for-association cdk2p1-cycE p57 p57-cdk2p1-cycE) 4)
	(= (prod-by-association p57 cdk2p1-cycE p57-cdk2p1-cycE) 4)
	(association-reaction p57 cdk46-cycDp1 p57-cdk46-cycDp1)
	(= (need-for-association p57 cdk46-cycDp1 p57-cdk46-cycDp1) 4)
	(= (need-for-association cdk46-cycDp1 p57 p57-cdk46-cycDp1) 1)
	(= (prod-by-association p57 cdk46-cycDp1 p57-cdk46-cycDp1) 1)
	(association-reaction p57 cdk46-cycD p57-cdk46-cycD)
	(= (need-for-association p57 cdk46-cycD p57-cdk46-cycD) 1)
	(= (need-for-association cdk46-cycD p57 p57-cdk46-cycD) 3)
	(= (prod-by-association p57 cdk46-cycD p57-cdk46-cycD) 1)
	(association-reaction p57 cdk46p1-cycDp1 p57-cdk46p1-cycDp1)
	(= (need-for-association p57 cdk46p1-cycDp1 p57-cdk46p1-cycDp1) 1)
	(= (need-for-association cdk46p1-cycDp1 p57 p57-cdk46p1-cycDp1) 2)
	(= (prod-by-association p57 cdk46p1-cycDp1 p57-cdk46p1-cycDp1) 1)
	(association-reaction p57 cdk46p1-cycD p57-cdk46p1-cycD)
	(= (need-for-association p57 cdk46p1-cycD p57-cdk46p1-cycD) 4)
	(= (need-for-association cdk46p1-cycD p57 p57-cdk46p1-cycD) 4)
	(= (prod-by-association p57 cdk46p1-cycD p57-cdk46p1-cycD) 2)
	(association-reaction p57p1 cdk46-cycDp1 p57p1-cdk46-cycDp1)
	(= (need-for-association p57p1 cdk46-cycDp1 p57p1-cdk46-cycDp1) 3)
	(= (need-for-association cdk46-cycDp1 p57p1 p57p1-cdk46-cycDp1) 4)
	(= (prod-by-association p57p1 cdk46-cycDp1 p57p1-cdk46-cycDp1) 2)
	(association-reaction p57p1 cdk46-cycD p57p1-cdk46-cycD)
	(= (need-for-association p57p1 cdk46-cycD p57p1-cdk46-cycD) 3)
	(= (need-for-association cdk46-cycD p57p1 p57p1-cdk46-cycD) 2)
	(= (prod-by-association p57p1 cdk46-cycD p57p1-cdk46-cycD) 4)
	(association-reaction p57p1 cdk46p1-cycDp1 p57p1-cdk46p1-cycDp1)
	(= (need-for-association p57p1 cdk46p1-cycDp1 p57p1-cdk46p1-cycDp1) 4)
	(= (need-for-association cdk46p1-cycDp1 p57p1 p57p1-cdk46p1-cycDp1) 4)
	(= (prod-by-association p57p1 cdk46p1-cycDp1 p57p1-cdk46p1-cycDp1) 3)
	(association-reaction p57p1 cdk46p1-cycD p57p1-cdk46p1-cycD)
	(= (need-for-association p57p1 cdk46p1-cycD p57p1-cdk46p1-cycD) 2)
	(= (need-for-association cdk46p1-cycD p57p1 p57p1-cdk46p1-cycD) 1)
	(= (prod-by-association p57p1 cdk46p1-cycD p57p1-cdk46p1-cycD) 3)
	(association-reaction pRb-E2F4p1-DP12 gE2 pRb-E2F4p1-DP12-gE2)
	(= (need-for-association pRb-E2F4p1-DP12 gE2 pRb-E2F4p1-DP12-gE2) 4)
	(= (need-for-association gE2 pRb-E2F4p1-DP12 pRb-E2F4p1-DP12-gE2) 2)
	(= (prod-by-association pRb-E2F4p1-DP12 gE2 pRb-E2F4p1-DP12-gE2) 3)
	(association-reaction pRbp1-E2F4p1-DP12 gE2 pRbp1-E2F4p1-DP12-gE2)
	(= (need-for-association pRbp1-E2F4p1-DP12 gE2 pRbp1-E2F4p1-DP12-gE2) 4)
	(= (need-for-association gE2 pRbp1-E2F4p1-DP12 pRbp1-E2F4p1-DP12-gE2) 4)
	(= (prod-by-association pRbp1-E2F4p1-DP12 gE2 pRbp1-E2F4p1-DP12-gE2) 3)
	(association-reaction pRbp1p2 Jun pRbp1p2-Jun)
	(= (need-for-association pRbp1p2 Jun pRbp1p2-Jun) 3)
	(= (need-for-association Jun pRbp1p2 pRbp1p2-Jun) 3)
	(= (prod-by-association pRbp1p2 Jun pRbp1p2-Jun) 3)
	(catalyzed-association-reaction pRbp2 cdk46p3-cycD pRbp1p2)
	(= (need-for-catalyzed-association pRbp2 cdk46p3-cycD pRbp1p2) 4)
	(= (need-for-catalyzed-association cdk46p3-cycD pRbp2 pRbp1p2) 3)
	(= (prod-by-catalyzed-association pRbp2 cdk46p3-cycD pRbp1p2) 1)
	(association-reaction pRbp2 Jun pRbp2-Jun)
	(= (need-for-association pRbp2 Jun pRbp2-Jun) 4)
	(= (need-for-association Jun pRbp2 pRbp2-Jun) 4)
	(= (prod-by-association pRbp2 Jun pRbp2-Jun) 3)
	(association-reaction Raf1 cdc25Ap1 Raf1-cdc25Ap1)
	(= (need-for-association Raf1 cdc25Ap1 Raf1-cdc25Ap1) 1)
	(= (need-for-association cdc25Ap1 Raf1 Raf1-cdc25Ap1) 3)
	(= (prod-by-association Raf1 cdc25Ap1 Raf1-cdc25Ap1) 2)
	(association-reaction Raf1 cdc25A Raf1-cdc25A)
	(= (need-for-association Raf1 cdc25A Raf1-cdc25A) 2)
	(= (need-for-association cdc25A Raf1 Raf1-cdc25A) 1)
	(= (prod-by-association Raf1 cdc25A Raf1-cdc25A) 2)
	(synthesis-reaction Raf1-p130-E2F4-DP12-gE2 c-Myc) 
	(= (need-for-synthesis Raf1-p130-E2F4-DP12-gE2 c-Myc) 3)
	(= (prod-by-synthesis Raf1-p130-E2F4-DP12-gE2 c-Myc) 3)
	(synthesis-reaction Raf1-p130-E2F4-DP12-gE2 cycA) 
	(= (need-for-synthesis Raf1-p130-E2F4-DP12-gE2 cycA) 3)
	(= (prod-by-synthesis Raf1-p130-E2F4-DP12-gE2 cycA) 2)
	(synthesis-reaction Raf1-p130-E2F4-DP12-gE2 cycD) 
	(= (need-for-synthesis Raf1-p130-E2F4-DP12-gE2 cycD) 2)
	(= (prod-by-synthesis Raf1-p130-E2F4-DP12-gE2 cycD) 3)
	(synthesis-reaction Raf1-p130-E2F4-DP12-gE2 cycDp1) 
	(= (need-for-synthesis Raf1-p130-E2F4-DP12-gE2 cycDp1) 4)
	(= (prod-by-synthesis Raf1-p130-E2F4-DP12-gE2 cycDp1) 3)
	(synthesis-reaction Raf1-p130-E2F4-DP12-gE2 cycE) 
	(= (need-for-synthesis Raf1-p130-E2F4-DP12-gE2 cycE) 3)
	(= (prod-by-synthesis Raf1-p130-E2F4-DP12-gE2 cycE) 3)
	(synthesis-reaction Raf1-p130-E2F4-DP12-gE2 cycEp1) 
	(= (need-for-synthesis Raf1-p130-E2F4-DP12-gE2 cycEp1) 3)
	(= (prod-by-synthesis Raf1-p130-E2F4-DP12-gE2 cycEp1) 4)
	(synthesis-reaction Raf1-p130-E2F4-DP12-gE2 p107) 
	(= (need-for-synthesis Raf1-p130-E2F4-DP12-gE2 p107) 1)
	(= (prod-by-synthesis Raf1-p130-E2F4-DP12-gE2 p107) 2)
	(synthesis-reaction Raf1-p130-E2F4-DP12-gE2 p107p1) 
	(= (need-for-synthesis Raf1-p130-E2F4-DP12-gE2 p107p1) 3)
	(= (prod-by-synthesis Raf1-p130-E2F4-DP12-gE2 p107p1) 3)
	(synthesis-reaction Raf1-p130-E2F4-DP12-gE2 p19ARF) 
	(= (need-for-synthesis Raf1-p130-E2F4-DP12-gE2 p19ARF) 4)
	(= (prod-by-synthesis Raf1-p130-E2F4-DP12-gE2 p19ARF) 1)
	(synthesis-reaction Raf1-p130-E2F4-DP12-gE2 pol) 
	(= (need-for-synthesis Raf1-p130-E2F4-DP12-gE2 pol) 1)
	(= (prod-by-synthesis Raf1-p130-E2F4-DP12-gE2 pol) 3)
	(association-reaction Raf1-p130-E2F4-DP12 gE2 Raf1-p130-E2F4-DP12-gE2)
	(= (need-for-association Raf1-p130-E2F4-DP12 gE2 Raf1-p130-E2F4-DP12-gE2) 4)
	(= (need-for-association gE2 Raf1-p130-E2F4-DP12 Raf1-p130-E2F4-DP12-gE2) 2)
	(= (prod-by-association Raf1-p130-E2F4-DP12 gE2 Raf1-p130-E2F4-DP12-gE2) 3)
	(association-reaction Raf1 p130-E2F4-DP12 Raf1-p130-E2F4-DP12)
	(= (need-for-association Raf1 p130-E2F4-DP12 Raf1-p130-E2F4-DP12) 3)
	(= (need-for-association p130-E2F4-DP12 Raf1 Raf1-p130-E2F4-DP12) 4)
	(= (prod-by-association Raf1 p130-E2F4-DP12 Raf1-p130-E2F4-DP12) 3)
	(synthesis-reaction Raf1-p130-E2F4p1-DP12-gE2 c-Myc) 
	(= (need-for-synthesis Raf1-p130-E2F4p1-DP12-gE2 c-Myc) 1)
	(= (prod-by-synthesis Raf1-p130-E2F4p1-DP12-gE2 c-Myc) 1)
	(synthesis-reaction Raf1-p130-E2F4p1-DP12-gE2 cycA) 
	(= (need-for-synthesis Raf1-p130-E2F4p1-DP12-gE2 cycA) 4)
	(= (prod-by-synthesis Raf1-p130-E2F4p1-DP12-gE2 cycA) 1)
	(synthesis-reaction Raf1-p130-E2F4p1-DP12-gE2 cycD) 
	(= (need-for-synthesis Raf1-p130-E2F4p1-DP12-gE2 cycD) 2)
	(= (prod-by-synthesis Raf1-p130-E2F4p1-DP12-gE2 cycD) 2)
	(synthesis-reaction Raf1-p130-E2F4p1-DP12-gE2 cycDp1) 
	(= (need-for-synthesis Raf1-p130-E2F4p1-DP12-gE2 cycDp1) 4)
	(= (prod-by-synthesis Raf1-p130-E2F4p1-DP12-gE2 cycDp1) 1)
	(synthesis-reaction Raf1-p130-E2F4p1-DP12-gE2 cycE) 
	(= (need-for-synthesis Raf1-p130-E2F4p1-DP12-gE2 cycE) 3)
	(= (prod-by-synthesis Raf1-p130-E2F4p1-DP12-gE2 cycE) 1)
	(synthesis-reaction Raf1-p130-E2F4p1-DP12-gE2 cycEp1) 
	(= (need-for-synthesis Raf1-p130-E2F4p1-DP12-gE2 cycEp1) 3)
	(= (prod-by-synthesis Raf1-p130-E2F4p1-DP12-gE2 cycEp1) 3)
	(synthesis-reaction Raf1-p130-E2F4p1-DP12-gE2 p107) 
	(= (need-for-synthesis Raf1-p130-E2F4p1-DP12-gE2 p107) 4)
	(= (prod-by-synthesis Raf1-p130-E2F4p1-DP12-gE2 p107) 1)
	(synthesis-reaction Raf1-p130-E2F4p1-DP12-gE2 p107p1) 
	(= (need-for-synthesis Raf1-p130-E2F4p1-DP12-gE2 p107p1) 1)
	(= (prod-by-synthesis Raf1-p130-E2F4p1-DP12-gE2 p107p1) 2)
	(synthesis-reaction Raf1-p130-E2F4p1-DP12-gE2 p19ARF) 
	(= (need-for-synthesis Raf1-p130-E2F4p1-DP12-gE2 p19ARF) 1)
	(= (prod-by-synthesis Raf1-p130-E2F4p1-DP12-gE2 p19ARF) 1)
	(synthesis-reaction Raf1-p130-E2F4p1-DP12-gE2 pol) 
	(= (need-for-synthesis Raf1-p130-E2F4p1-DP12-gE2 pol) 3)
	(= (prod-by-synthesis Raf1-p130-E2F4p1-DP12-gE2 pol) 3)
	(association-reaction Raf1-p130-E2F4p1-DP12 gE2 Raf1-p130-E2F4p1-DP12-gE2)
	(= (need-for-association Raf1-p130-E2F4p1-DP12 gE2 Raf1-p130-E2F4p1-DP12-gE2) 4)
	(= (need-for-association gE2 Raf1-p130-E2F4p1-DP12 Raf1-p130-E2F4p1-DP12-gE2) 2)
	(= (prod-by-association Raf1-p130-E2F4p1-DP12 gE2 Raf1-p130-E2F4p1-DP12-gE2) 4)
	(association-reaction Raf1 p130-E2F4p1-DP12 Raf1-p130-E2F4p1-DP12)
	(= (need-for-association Raf1 p130-E2F4p1-DP12 Raf1-p130-E2F4p1-DP12) 4)
	(= (need-for-association p130-E2F4p1-DP12 Raf1 Raf1-p130-E2F4p1-DP12) 1)
	(= (prod-by-association Raf1 p130-E2F4p1-DP12 Raf1-p130-E2F4p1-DP12) 3)
	(synthesis-reaction Raf1-p130-E2F5-DP12-gE2 c-Myc) 
	(= (need-for-synthesis Raf1-p130-E2F5-DP12-gE2 c-Myc) 1)
	(= (prod-by-synthesis Raf1-p130-E2F5-DP12-gE2 c-Myc) 3)
	(synthesis-reaction Raf1-p130-E2F5-DP12-gE2 cycA) 
	(= (need-for-synthesis Raf1-p130-E2F5-DP12-gE2 cycA) 1)
	(= (prod-by-synthesis Raf1-p130-E2F5-DP12-gE2 cycA) 4)
	(synthesis-reaction Raf1-p130-E2F5-DP12-gE2 cycD) 
	(= (need-for-synthesis Raf1-p130-E2F5-DP12-gE2 cycD) 1)
	(= (prod-by-synthesis Raf1-p130-E2F5-DP12-gE2 cycD) 1)
	(synthesis-reaction Raf1-p130-E2F5-DP12-gE2 cycDp1) 
	(= (need-for-synthesis Raf1-p130-E2F5-DP12-gE2 cycDp1) 1)
	(= (prod-by-synthesis Raf1-p130-E2F5-DP12-gE2 cycDp1) 4)
	(synthesis-reaction Raf1-p130-E2F5-DP12-gE2 cycE) 
	(= (need-for-synthesis Raf1-p130-E2F5-DP12-gE2 cycE) 1)
	(= (prod-by-synthesis Raf1-p130-E2F5-DP12-gE2 cycE) 2)
	(synthesis-reaction Raf1-p130-E2F5-DP12-gE2 cycEp1) 
	(= (need-for-synthesis Raf1-p130-E2F5-DP12-gE2 cycEp1) 1)
	(= (prod-by-synthesis Raf1-p130-E2F5-DP12-gE2 cycEp1) 4)
	(synthesis-reaction Raf1-p130-E2F5-DP12-gE2 p107) 
	(= (need-for-synthesis Raf1-p130-E2F5-DP12-gE2 p107) 2)
	(= (prod-by-synthesis Raf1-p130-E2F5-DP12-gE2 p107) 3)
	(synthesis-reaction Raf1-p130-E2F5-DP12-gE2 p107p1) 
	(= (need-for-synthesis Raf1-p130-E2F5-DP12-gE2 p107p1) 1)
	(= (prod-by-synthesis Raf1-p130-E2F5-DP12-gE2 p107p1) 4)
	(synthesis-reaction Raf1-p130-E2F5-DP12-gE2 p19ARF) 
	(= (need-for-synthesis Raf1-p130-E2F5-DP12-gE2 p19ARF) 1)
	(= (prod-by-synthesis Raf1-p130-E2F5-DP12-gE2 p19ARF) 4)
	(synthesis-reaction Raf1-p130-E2F5-DP12-gE2 pol) 
	(= (need-for-synthesis Raf1-p130-E2F5-DP12-gE2 pol) 1)
	(= (prod-by-synthesis Raf1-p130-E2F5-DP12-gE2 pol) 1)
	(association-reaction Raf1-p130-E2F5-DP12 gE2 Raf1-p130-E2F5-DP12-gE2)
	(= (need-for-association Raf1-p130-E2F5-DP12 gE2 Raf1-p130-E2F5-DP12-gE2) 1)
	(= (need-for-association gE2 Raf1-p130-E2F5-DP12 Raf1-p130-E2F5-DP12-gE2) 1)
	(= (prod-by-association Raf1-p130-E2F5-DP12 gE2 Raf1-p130-E2F5-DP12-gE2) 2)
	(association-reaction Raf1 p130-E2F5-DP12 Raf1-p130-E2F5-DP12)
	(= (need-for-association Raf1 p130-E2F5-DP12 Raf1-p130-E2F5-DP12) 3)
	(= (need-for-association p130-E2F5-DP12 Raf1 Raf1-p130-E2F5-DP12) 3)
	(= (prod-by-association Raf1 p130-E2F5-DP12 Raf1-p130-E2F5-DP12) 1)
	(synthesis-reaction Raf1-p130-E2F5p1-DP12-gE2 c-Myc) 
	(= (need-for-synthesis Raf1-p130-E2F5p1-DP12-gE2 c-Myc) 4)
	(= (prod-by-synthesis Raf1-p130-E2F5p1-DP12-gE2 c-Myc) 2)
	(synthesis-reaction Raf1-p130-E2F5p1-DP12-gE2 cycA) 
	(= (need-for-synthesis Raf1-p130-E2F5p1-DP12-gE2 cycA) 4)
	(= (prod-by-synthesis Raf1-p130-E2F5p1-DP12-gE2 cycA) 4)
	(synthesis-reaction Raf1-p130-E2F5p1-DP12-gE2 cycD) 
	(= (need-for-synthesis Raf1-p130-E2F5p1-DP12-gE2 cycD) 4)
	(= (prod-by-synthesis Raf1-p130-E2F5p1-DP12-gE2 cycD) 1)
	(synthesis-reaction Raf1-p130-E2F5p1-DP12-gE2 cycDp1) 
	(= (need-for-synthesis Raf1-p130-E2F5p1-DP12-gE2 cycDp1) 2)
	(= (prod-by-synthesis Raf1-p130-E2F5p1-DP12-gE2 cycDp1) 4)
	(synthesis-reaction Raf1-p130-E2F5p1-DP12-gE2 cycE) 
	(= (need-for-synthesis Raf1-p130-E2F5p1-DP12-gE2 cycE) 4)
	(= (prod-by-synthesis Raf1-p130-E2F5p1-DP12-gE2 cycE) 2)
	(synthesis-reaction Raf1-p130-E2F5p1-DP12-gE2 cycEp1) 
	(= (need-for-synthesis Raf1-p130-E2F5p1-DP12-gE2 cycEp1) 4)
	(= (prod-by-synthesis Raf1-p130-E2F5p1-DP12-gE2 cycEp1) 4)
	(synthesis-reaction Raf1-p130-E2F5p1-DP12-gE2 p107) 
	(= (need-for-synthesis Raf1-p130-E2F5p1-DP12-gE2 p107) 1)
	(= (prod-by-synthesis Raf1-p130-E2F5p1-DP12-gE2 p107) 1)
	(synthesis-reaction Raf1-p130-E2F5p1-DP12-gE2 p107p1) 
	(= (need-for-synthesis Raf1-p130-E2F5p1-DP12-gE2 p107p1) 2)
	(= (prod-by-synthesis Raf1-p130-E2F5p1-DP12-gE2 p107p1) 1)
	(synthesis-reaction Raf1-p130-E2F5p1-DP12-gE2 p19ARF) 
	(= (need-for-synthesis Raf1-p130-E2F5p1-DP12-gE2 p19ARF) 4)
	(= (prod-by-synthesis Raf1-p130-E2F5p1-DP12-gE2 p19ARF) 3)
	(synthesis-reaction Raf1-p130-E2F5p1-DP12-gE2 pol) 
	(= (need-for-synthesis Raf1-p130-E2F5p1-DP12-gE2 pol) 4)
	(= (prod-by-synthesis Raf1-p130-E2F5p1-DP12-gE2 pol) 4)
	(association-reaction Raf1-p130-E2F5p1-DP12 gE2 Raf1-p130-E2F5p1-DP12-gE2)
	(= (need-for-association Raf1-p130-E2F5p1-DP12 gE2 Raf1-p130-E2F5p1-DP12-gE2) 3)
	(= (need-for-association gE2 Raf1-p130-E2F5p1-DP12 Raf1-p130-E2F5p1-DP12-gE2) 4)
	(= (prod-by-association Raf1-p130-E2F5p1-DP12 gE2 Raf1-p130-E2F5p1-DP12-gE2) 3)
	(association-reaction Raf1 p130-E2F5p1-DP12 Raf1-p130-E2F5p1-DP12)
	(= (need-for-association Raf1 p130-E2F5p1-DP12 Raf1-p130-E2F5p1-DP12) 3)
	(= (need-for-association p130-E2F5p1-DP12 Raf1 Raf1-p130-E2F5p1-DP12) 1)
	(= (prod-by-association Raf1 p130-E2F5p1-DP12 Raf1-p130-E2F5p1-DP12) 3)
	(synthesis-reaction Raf1-pRb-E2F4p1-DP12-gE2 c-Myc) 
	(= (need-for-synthesis Raf1-pRb-E2F4p1-DP12-gE2 c-Myc) 3)
	(= (prod-by-synthesis Raf1-pRb-E2F4p1-DP12-gE2 c-Myc) 2)
	(synthesis-reaction Raf1-pRb-E2F4p1-DP12-gE2 cycA) 
	(= (need-for-synthesis Raf1-pRb-E2F4p1-DP12-gE2 cycA) 1)
	(= (prod-by-synthesis Raf1-pRb-E2F4p1-DP12-gE2 cycA) 1)
	(synthesis-reaction Raf1-pRb-E2F4p1-DP12-gE2 cycD) 
	(= (need-for-synthesis Raf1-pRb-E2F4p1-DP12-gE2 cycD) 2)
	(= (prod-by-synthesis Raf1-pRb-E2F4p1-DP12-gE2 cycD) 1)
	(synthesis-reaction Raf1-pRb-E2F4p1-DP12-gE2 cycDp1) 
	(= (need-for-synthesis Raf1-pRb-E2F4p1-DP12-gE2 cycDp1) 3)
	(= (prod-by-synthesis Raf1-pRb-E2F4p1-DP12-gE2 cycDp1) 1)
	(synthesis-reaction Raf1-pRb-E2F4p1-DP12-gE2 cycE) 
	(= (need-for-synthesis Raf1-pRb-E2F4p1-DP12-gE2 cycE) 4)
	(= (prod-by-synthesis Raf1-pRb-E2F4p1-DP12-gE2 cycE) 2)
	(synthesis-reaction Raf1-pRb-E2F4p1-DP12-gE2 cycEp1) 
	(= (need-for-synthesis Raf1-pRb-E2F4p1-DP12-gE2 cycEp1) 1)
	(= (prod-by-synthesis Raf1-pRb-E2F4p1-DP12-gE2 cycEp1) 2)
	(synthesis-reaction Raf1-pRb-E2F4p1-DP12-gE2 p107) 
	(= (need-for-synthesis Raf1-pRb-E2F4p1-DP12-gE2 p107) 2)
	(= (prod-by-synthesis Raf1-pRb-E2F4p1-DP12-gE2 p107) 1)
	(synthesis-reaction Raf1-pRb-E2F4p1-DP12-gE2 p107p1) 
	(= (need-for-synthesis Raf1-pRb-E2F4p1-DP12-gE2 p107p1) 3)
	(= (prod-by-synthesis Raf1-pRb-E2F4p1-DP12-gE2 p107p1) 1)
	(synthesis-reaction Raf1-pRb-E2F4p1-DP12-gE2 p19ARF) 
	(= (need-for-synthesis Raf1-pRb-E2F4p1-DP12-gE2 p19ARF) 4)
	(= (prod-by-synthesis Raf1-pRb-E2F4p1-DP12-gE2 p19ARF) 4)
	(synthesis-reaction Raf1-pRb-E2F4p1-DP12-gE2 pol) 
	(= (need-for-synthesis Raf1-pRb-E2F4p1-DP12-gE2 pol) 1)
	(= (prod-by-synthesis Raf1-pRb-E2F4p1-DP12-gE2 pol) 1)
	(association-reaction Raf1-pRb-E2F4p1-DP12 gE2 Raf1-pRb-E2F4p1-DP12-gE2)
	(= (need-for-association Raf1-pRb-E2F4p1-DP12 gE2 Raf1-pRb-E2F4p1-DP12-gE2) 4)
	(= (need-for-association gE2 Raf1-pRb-E2F4p1-DP12 Raf1-pRb-E2F4p1-DP12-gE2) 1)
	(= (prod-by-association Raf1-pRb-E2F4p1-DP12 gE2 Raf1-pRb-E2F4p1-DP12-gE2) 4)
	(association-reaction Raf1 pRb-E2F4p1-DP12 Raf1-pRb-E2F4p1-DP12)
	(= (need-for-association Raf1 pRb-E2F4p1-DP12 Raf1-pRb-E2F4p1-DP12) 3)
	(= (need-for-association pRb-E2F4p1-DP12 Raf1 Raf1-pRb-E2F4p1-DP12) 4)
	(= (prod-by-association Raf1 pRb-E2F4p1-DP12 Raf1-pRb-E2F4p1-DP12) 2)
	(synthesis-reaction Raf1-pRbp1-E2F4p1-DP12-gE2 c-Myc) 
	(= (need-for-synthesis Raf1-pRbp1-E2F4p1-DP12-gE2 c-Myc) 3)
	(= (prod-by-synthesis Raf1-pRbp1-E2F4p1-DP12-gE2 c-Myc) 3)
	(synthesis-reaction Raf1-pRbp1-E2F4p1-DP12-gE2 cycA) 
	(= (need-for-synthesis Raf1-pRbp1-E2F4p1-DP12-gE2 cycA) 4)
	(= (prod-by-synthesis Raf1-pRbp1-E2F4p1-DP12-gE2 cycA) 3)
	(synthesis-reaction Raf1-pRbp1-E2F4p1-DP12-gE2 cycD) 
	(= (need-for-synthesis Raf1-pRbp1-E2F4p1-DP12-gE2 cycD) 1)
	(= (prod-by-synthesis Raf1-pRbp1-E2F4p1-DP12-gE2 cycD) 2)
	(synthesis-reaction Raf1-pRbp1-E2F4p1-DP12-gE2 cycDp1) 
	(= (need-for-synthesis Raf1-pRbp1-E2F4p1-DP12-gE2 cycDp1) 4)
	(= (prod-by-synthesis Raf1-pRbp1-E2F4p1-DP12-gE2 cycDp1) 2)
	(synthesis-reaction Raf1-pRbp1-E2F4p1-DP12-gE2 cycE) 
	(= (need-for-synthesis Raf1-pRbp1-E2F4p1-DP12-gE2 cycE) 2)
	(= (prod-by-synthesis Raf1-pRbp1-E2F4p1-DP12-gE2 cycE) 1)
	(synthesis-reaction Raf1-pRbp1-E2F4p1-DP12-gE2 cycEp1) 
	(= (need-for-synthesis Raf1-pRbp1-E2F4p1-DP12-gE2 cycEp1) 2)
	(= (prod-by-synthesis Raf1-pRbp1-E2F4p1-DP12-gE2 cycEp1) 4)
	(synthesis-reaction Raf1-pRbp1-E2F4p1-DP12-gE2 p107) 
	(= (need-for-synthesis Raf1-pRbp1-E2F4p1-DP12-gE2 p107) 1)
	(= (prod-by-synthesis Raf1-pRbp1-E2F4p1-DP12-gE2 p107) 1)
	(synthesis-reaction Raf1-pRbp1-E2F4p1-DP12-gE2 p107p1) 
	(= (need-for-synthesis Raf1-pRbp1-E2F4p1-DP12-gE2 p107p1) 2)
	(= (prod-by-synthesis Raf1-pRbp1-E2F4p1-DP12-gE2 p107p1) 2)
	(synthesis-reaction Raf1-pRbp1-E2F4p1-DP12-gE2 p19ARF) 
	(= (need-for-synthesis Raf1-pRbp1-E2F4p1-DP12-gE2 p19ARF) 2)
	(= (prod-by-synthesis Raf1-pRbp1-E2F4p1-DP12-gE2 p19ARF) 3)
	(synthesis-reaction Raf1-pRbp1-E2F4p1-DP12-gE2 pol) 
	(= (need-for-synthesis Raf1-pRbp1-E2F4p1-DP12-gE2 pol) 2)
	(= (prod-by-synthesis Raf1-pRbp1-E2F4p1-DP12-gE2 pol) 1)
	(association-reaction Raf1-pRbp1-E2F4p1-DP12 gE2 Raf1-pRbp1-E2F4p1-DP12-gE2)
	(= (need-for-association Raf1-pRbp1-E2F4p1-DP12 gE2 Raf1-pRbp1-E2F4p1-DP12-gE2) 3)
	(= (need-for-association gE2 Raf1-pRbp1-E2F4p1-DP12 Raf1-pRbp1-E2F4p1-DP12-gE2) 1)
	(= (prod-by-association Raf1-pRbp1-E2F4p1-DP12 gE2 Raf1-pRbp1-E2F4p1-DP12-gE2) 4)
	(association-reaction Raf1 pRbp1-E2F4p1-DP12 Raf1-pRbp1-E2F4p1-DP12)
	(= (need-for-association Raf1 pRbp1-E2F4p1-DP12 Raf1-pRbp1-E2F4p1-DP12) 4)
	(= (need-for-association pRbp1-E2F4p1-DP12 Raf1 Raf1-pRbp1-E2F4p1-DP12) 2)
	(= (prod-by-association Raf1 pRbp1-E2F4p1-DP12 Raf1-pRbp1-E2F4p1-DP12) 3)
	(association-reaction RPA cycA RPA-cycA)
	(= (need-for-association RPA cycA RPA-cycA) 4)
	(= (need-for-association cycA RPA RPA-cycA) 1)
	(= (prod-by-association RPA cycA RPA-cycA) 2)
	(association-reaction Skp2 cdk2-cycA Skp2-cdk2-cycA)
	(= (need-for-association Skp2 cdk2-cycA Skp2-cdk2-cycA) 3)
	(= (need-for-association cdk2-cycA Skp2 Skp2-cdk2-cycA) 2)
	(= (prod-by-association Skp2 cdk2-cycA Skp2-cdk2-cycA) 4)
	(association-reaction Skp2 cdk2p1-cycA Skp2-cdk2p1-cycA)
	(= (need-for-association Skp2 cdk2p1-cycA Skp2-cdk2p1-cycA) 1)
	(= (need-for-association cdk2p1-cycA Skp2 Skp2-cdk2p1-cycA) 1)
	(= (prod-by-association Skp2 cdk2p1-cycA Skp2-cdk2p1-cycA) 2)
	(association-reaction Skp2-Skp1 cdk2-cycA Skp2-Skp1-cdk2-cycA)
	(= (need-for-association Skp2-Skp1 cdk2-cycA Skp2-Skp1-cdk2-cycA) 2)
	(= (need-for-association cdk2-cycA Skp2-Skp1 Skp2-Skp1-cdk2-cycA) 2)
	(= (prod-by-association Skp2-Skp1 cdk2-cycA Skp2-Skp1-cdk2-cycA) 1)
	(association-reaction Skp2-Skp1 cdk2p1-cycA Skp2-Skp1-cdk2p1-cycA)
	(= (need-for-association Skp2-Skp1 cdk2p1-cycA Skp2-Skp1-cdk2p1-cycA) 3)
	(= (need-for-association cdk2p1-cycA Skp2-Skp1 Skp2-Skp1-cdk2p1-cycA) 3)
	(= (prod-by-association Skp2-Skp1 cdk2p1-cycA Skp2-Skp1-cdk2p1-cycA) 1)
	(association-reaction Skp2 Skp1 Skp2-Skp1)
	(= (need-for-association Skp2 Skp1 Skp2-Skp1) 4)
	(= (need-for-association Skp1 Skp2 Skp2-Skp1) 3)
	(= (prod-by-association Skp2 Skp1 Skp2-Skp1) 1)
	(association-reaction SP1 E2F13 SP1-E2F13)
	(= (need-for-association SP1 E2F13 SP1-E2F13) 4)
	(= (need-for-association E2F13 SP1 SP1-E2F13) 4)
	(= (prod-by-association SP1 E2F13 SP1-E2F13) 2)
	(association-reaction SP1 p107p1 SP1-p107p1)
	(= (need-for-association SP1 p107p1 SP1-p107p1) 2)
	(= (need-for-association p107p1 SP1 SP1-p107p1) 2)
	(= (prod-by-association SP1 p107p1 SP1-p107p1) 3)
	(association-reaction SP1 p107 SP1-p107)
	(= (need-for-association SP1 p107 SP1-p107) 2)
	(= (need-for-association p107 SP1 SP1-p107) 4)
	(= (prod-by-association SP1 p107 SP1-p107) 4)
	(= (num-subs) 0)
	(= (duration-catalyzed-association-reaction APC Plk1 APCp1) 2.1)
	(= (duration-catalyzed-association-reaction cdc25A Raf1 cdc25Ap1) 2.2)
	(= (duration-association-reaction cdk2-cycA E2F13 cdk2-cycA-E2F13) 1.1)
	(= (duration-catalyzed-association-reaction cdk2p1-cycA cdc25Ap1 cdk2-cycA) 2.0)
	(= (duration-association-reaction cdk2p1 cycA cdk2p1-cycA) 0.8)
	(= (duration-association-reaction cdk2p1-cycA E2F13 cdk2p1-cycA-E2F13) 1.0)
	(= (duration-catalyzed-association-reaction cdk2p1-cycE cdc25Ap1 cdk2-cycE) 1.9)
	(= (duration-association-reaction cdk2p1 cycE cdk2p1-cycE) 1.0)
	(= (duration-catalyzed-association-reaction cdk2p1-cycEp1 cdc25Ap1 cdk2-cycEp1) 1.7)
	(= (duration-association-reaction cdk2p1 cycEp1 cdk2p1-cycEp1) 1.1)
	(= (duration-association-reaction cdk46 cycD cdk46-cycD) 0.9)
	(= (duration-association-reaction cdk46 cycDp1 cdk46-cycDp1) 1.0)
	(= (duration-catalyzed-association-reaction cdk46p1 cdc25Ap1 cdk46) 2.2)
	(= (duration-association-reaction cdk46p1 cycD cdk46p1-cycD) 0.9)
	(= (duration-association-reaction cdk46p1 cycDp1 cdk46p1-cycDp1) 1.1)
	(= (duration-association-reaction c-Myc Max c-Myc-Max) 1.1)
	(= (duration-synthesis-reaction c-Myc-Max-gcdc25A cdc25A) 3.4)
	(= (duration-association-reaction c-Myc-Max gcdc25A c-Myc-Max-gcdc25A) 1.1)
	(= (duration-catalyzed-association-reaction cycA Skp2-Skp1 Skp2-Skp1) 1.9)
	(= (duration-catalyzed-association-reaction DMP1 cdk46p3-cycD DMP1p1) 2.0)
	(= (duration-association-reaction DMP1 cycD DMP1-cycD) 0.9)
	(= (duration-association-reaction DMP1 cycDp1 DMP1-cycDp1) 1.1)
	(= (duration-association-reaction DMP1 gp19ARF DMP1-gp19ARF) 1.1)
	(= (duration-association-reaction DMP1p1 cycD DMP1p1-cycD) 1.1)
	(= (duration-association-reaction DMP1p1 cycDp1 DMP1p1-cycDp1) 1.0)
	(= (duration-association-reaction DMP1p1 gp19ARF DMP1p1-gp19ARF) 1.1)
	(= (duration-synthesis-reaction DMP1p1-gp19ARF p19ARF) 3.9)
	(= (duration-synthesis-reaction E2F13-DP12-gE2 c-Myc) 3.5)
	(= (duration-synthesis-reaction E2F13-DP12-gE2 cycA) 3.5)
	(= (duration-synthesis-reaction E2F13-DP12-gE2 cycD) 3.6)
	(= (duration-synthesis-reaction E2F13-DP12-gE2 cycDp1) 4.1)
	(= (duration-synthesis-reaction E2F13-DP12-gE2 cycE) 4.5)
	(= (duration-synthesis-reaction E2F13-DP12-gE2 cycEp1) 3.3)
	(= (duration-association-reaction E2F13-DP12 gE2 E2F13-DP12-gE2) 0.8)
	(= (duration-synthesis-reaction E2F13-DP12-gE2 p107) 3.3)
	(= (duration-synthesis-reaction E2F13-DP12-gE2 p107p1) 4.2)
	(= (duration-synthesis-reaction E2F13-DP12-gE2 p19ARF) 4.1)
	(= (duration-synthesis-reaction E2F13-DP12-gE2 pol) 4.5)
	(= (duration-synthesis-reaction E2F13p1-DP12-gE2 c-Myc) 3.4)
	(= (duration-synthesis-reaction E2F13p1-DP12-gE2 cycA) 3.5)
	(= (duration-synthesis-reaction E2F13p1-DP12-gE2 cycD) 4.3)
	(= (duration-synthesis-reaction E2F13p1-DP12-gE2 cycDp1) 4.5)
	(= (duration-synthesis-reaction E2F13p1-DP12-gE2 cycE) 3.6)
	(= (duration-synthesis-reaction E2F13p1-DP12-gE2 cycEp1) 3.3)
	(= (duration-association-reaction E2F13p1-DP12 gE2 E2F13p1-DP12-gE2) 1.1)
	(= (duration-synthesis-reaction E2F13p1-DP12-gE2 p107) 4.2)
	(= (duration-synthesis-reaction E2F13p1-DP12-gE2 p107p1) 4.5)
	(= (duration-synthesis-reaction E2F13p1-DP12-gE2 p19ARF) 4.4)
	(= (duration-synthesis-reaction E2F13p1-DP12-gE2 pol) 4.2)
	(= (duration-association-reaction E2F1 DP12 E2F1-DP12) 1.1)
	(= (duration-association-reaction E2F3 DP12 E2F3-DP12) 1.1)
	(= (duration-association-reaction E2F4 DP12 E2F4-DP12) 1.1)
	(= (duration-synthesis-reaction E2F4-DP12-gE2 c-Myc) 4.2)
	(= (duration-synthesis-reaction E2F4-DP12-gE2 cycA) 4.2)
	(= (duration-synthesis-reaction E2F4-DP12-gE2 cycD) 3.4)
	(= (duration-synthesis-reaction E2F4-DP12-gE2 cycDp1) 4.4)
	(= (duration-synthesis-reaction E2F4-DP12-gE2 cycE) 4.6)
	(= (duration-synthesis-reaction E2F4-DP12-gE2 cycEp1) 4.1)
	(= (duration-association-reaction E2F4-DP12 gE2 E2F4-DP12-gE2) 1.0)
	(= (duration-synthesis-reaction E2F4-DP12-gE2 p107) 4.2)
	(= (duration-synthesis-reaction E2F4-DP12-gE2 p107p1) 4.5)
	(= (duration-synthesis-reaction E2F4-DP12-gE2 p19ARF) 4.1)
	(= (duration-synthesis-reaction E2F4-DP12-gE2 pol) 3.4)
	(= (duration-association-reaction E2F5 DP12 E2F5-DP12) 1.0)
	(= (duration-synthesis-reaction E2F5-DP12-gE2 c-Myc) 4.2)
	(= (duration-synthesis-reaction E2F5-DP12-gE2 cycA) 4.1)
	(= (duration-synthesis-reaction E2F5-DP12-gE2 cycD) 3.4)
	(= (duration-synthesis-reaction E2F5-DP12-gE2 cycDp1) 4.3)
	(= (duration-synthesis-reaction E2F5-DP12-gE2 cycE) 4.1)
	(= (duration-synthesis-reaction E2F5-DP12-gE2 cycEp1) 4.3)
	(= (duration-association-reaction E2F5-DP12 gE2 E2F5-DP12-gE2) 1.0)
	(= (duration-synthesis-reaction E2F5-DP12-gE2 p107) 4.4)
	(= (duration-synthesis-reaction E2F5-DP12-gE2 p107p1) 4.2)
	(= (duration-synthesis-reaction E2F5-DP12-gE2 p19ARF) 4.3)
	(= (duration-synthesis-reaction E2F5-DP12-gE2 pol) 3.7)
	(= (duration-association-reaction E2F6-DP12p1 gE2 E2F6-DP12p1-gE2) 1.0)
	(= (duration-association-reaction HDAC1-p107-E2F4-DP12 gE2 HDAC1-p107-E2F4-DP12-gE2) 1.0)
	(= (duration-association-reaction HDAC1 p107-E2F4-DP12 HDAC1-p107-E2F4-DP12) 0.9)
	(= (duration-association-reaction HDAC1 p107-E2F4-DP12p1 HDAC1-p107-E2F4-DP12p1) 1.1)
	(= (duration-association-reaction HDAC1-p130-E2F4-DP12 gE2 HDAC1-p130-E2F4-DP12-gE2) 1.1)
	(= (duration-association-reaction HDAC1 p130-E2F4-DP12 HDAC1-p130-E2F4-DP12) 1.0)
	(= (duration-association-reaction HDAC1 p130-E2F4-DP12p1 HDAC1-p130-E2F4-DP12p1) 1.1)
	(= (duration-association-reaction HDAC1-p130-E2F5-DP12 gE2 HDAC1-p130-E2F5-DP12-gE2) 1.0)
	(= (duration-association-reaction HDAC1 p130-E2F5-DP12 HDAC1-p130-E2F5-DP12) 0.9)
	(= (duration-association-reaction HDAC1 pRb-E2F4p1-DP12 HDAC1-pRb-E2F4p1-DP12) 1.1)
	(= (duration-association-reaction HDAC1-pRbp1-E2F13-DP12 gE2 HDAC1-pRbp1-E2F13-DP12-gE2) 0.9)
	(= (duration-association-reaction HDAC1-pRbp1-E2F13p1-DP12 gE2 HDAC1-pRbp1-E2F13p1-DP12-gE2) 0.9)
	(= (duration-association-reaction HDAC1-pRbp1-E2F4-DP12 gE2 HDAC1-pRbp1-E2F4-DP12-gE2) 0.9)
	(= (duration-association-reaction p107-E2F4-DP12 gE2 p107-E2F4-DP12-gE2) 1.1)
	(= (duration-association-reaction p107 E2F4-DP12 p107-E2F4-DP12) 0.9)
	(= (duration-association-reaction p107-E2F4-DP12p1 gE2 p107-E2F4-DP12p1-gE2) 0.8)
	(= (duration-association-reaction p107 E2F4-DP12p1 p107-E2F4-DP12p1) 0.9)
	(= (duration-association-reaction p130-E2F4-DP12 gE2 p130-E2F4-DP12-gE2) 1.1)
	(= (duration-association-reaction p130 E2F4-DP12 p130-E2F4-DP12) 1.1)
	(= (duration-association-reaction p130-E2F4-DP12p1 gE2 p130-E2F4-DP12p1-gE2) 1.1)
	(= (duration-association-reaction p130 E2F4-DP12p1 p130-E2F4-DP12p1) 0.8)
	(= (duration-association-reaction p130-E2F5-DP12 gE2 p130-E2F5-DP12-gE2) 0.9)
	(= (duration-association-reaction p130 E2F5-DP12 p130-E2F5-DP12) 1.0)
	(= (duration-association-reaction p27 cdk2-cycA p27-cdk2-cycA) 0.9)
	(= (duration-association-reaction p27 cdk2-cycEp1 p27-cdk2-cycEp1) 1.0)
	(= (duration-association-reaction p27 cdk2-cycE p27-cdk2-cycE) 0.9)
	(= (duration-association-reaction p27 cdk2p1-cycA p27-cdk2p1-cycA) 1.1)
	(= (duration-association-reaction p27 cdk2p1-cycEp1 p27-cdk2p1-cycEp1) 0.9)
	(= (duration-association-reaction p27 cdk2p1-cycE p27-cdk2p1-cycE) 0.9)
	(= (duration-association-reaction p27 cdk46-cycDp1 p27-cdk46-cycDp1) 0.8)
	(= (duration-association-reaction p27 cdk46-cycD p27-cdk46-cycD) 0.9)
	(= (duration-association-reaction p27 cdk46p1-cycDp1 p27-cdk46p1-cycDp1) 1.1)
	(= (duration-association-reaction p27 cdk46p1-cycD p27-cdk46p1-cycD) 0.8)
	(= (duration-association-reaction p57 cdk2-cycA p57-cdk2-cycA) 0.8)
	(= (duration-association-reaction p57 cdk2-cycEp1 p57-cdk2-cycEp1) 0.9)
	(= (duration-association-reaction p57 cdk2-cycE p57-cdk2-cycE) 1.1)
	(= (duration-association-reaction p57 cdk2p1-cycA p57-cdk2p1-cycA) 1.0)
	(= (duration-association-reaction p57 cdk2p1-cycEp1 p57-cdk2p1-cycEp1) 0.9)
	(= (duration-association-reaction p57 cdk2p1-cycE p57-cdk2p1-cycE) 1.1)
	(= (duration-association-reaction p57 cdk46-cycDp1 p57-cdk46-cycDp1) 1.1)
	(= (duration-association-reaction p57 cdk46-cycD p57-cdk46-cycD) 0.9)
	(= (duration-association-reaction p57 cdk46p1-cycDp1 p57-cdk46p1-cycDp1) 0.9)
	(= (duration-association-reaction p57 cdk46p1-cycD p57-cdk46p1-cycD) 1.0)
	(= (duration-association-reaction p57p1 cdk46-cycDp1 p57p1-cdk46-cycDp1) 1.0)
	(= (duration-association-reaction p57p1 cdk46-cycD p57p1-cdk46-cycD) 1.1)
	(= (duration-association-reaction p57p1 cdk46p1-cycDp1 p57p1-cdk46p1-cycDp1) 1.1)
	(= (duration-association-reaction p57p1 cdk46p1-cycD p57p1-cdk46p1-cycD) 0.9)
	(= (duration-association-reaction pRb-E2F4p1-DP12 gE2 pRb-E2F4p1-DP12-gE2) 0.9)
	(= (duration-association-reaction pRbp1-E2F4p1-DP12 gE2 pRbp1-E2F4p1-DP12-gE2) 0.8)
	(= (duration-association-reaction pRbp1p2 Jun pRbp1p2-Jun) 1.1)
	(= (duration-catalyzed-association-reaction pRbp2 cdk46p3-cycD pRbp1p2) 1.9)
	(= (duration-association-reaction pRbp2 Jun pRbp2-Jun) 0.9)
	(= (duration-association-reaction Raf1 cdc25Ap1 Raf1-cdc25Ap1) 1.1)
	(= (duration-association-reaction Raf1 cdc25A Raf1-cdc25A) 1.0)
	(= (duration-synthesis-reaction Raf1-p130-E2F4-DP12-gE2 c-Myc) 4.5)
	(= (duration-synthesis-reaction Raf1-p130-E2F4-DP12-gE2 cycA) 3.7)
	(= (duration-synthesis-reaction Raf1-p130-E2F4-DP12-gE2 cycD) 4.2)
	(= (duration-synthesis-reaction Raf1-p130-E2F4-DP12-gE2 cycDp1) 4.3)
	(= (duration-synthesis-reaction Raf1-p130-E2F4-DP12-gE2 cycE) 3.4)
	(= (duration-synthesis-reaction Raf1-p130-E2F4-DP12-gE2 cycEp1) 4.0)
	(= (duration-synthesis-reaction Raf1-p130-E2F4-DP12-gE2 p107) 3.7)
	(= (duration-synthesis-reaction Raf1-p130-E2F4-DP12-gE2 p107p1) 3.7)
	(= (duration-synthesis-reaction Raf1-p130-E2F4-DP12-gE2 p19ARF) 4.5)
	(= (duration-synthesis-reaction Raf1-p130-E2F4-DP12-gE2 pol) 3.8)
	(= (duration-association-reaction Raf1-p130-E2F4-DP12 gE2 Raf1-p130-E2F4-DP12-gE2) 0.9)
	(= (duration-association-reaction Raf1 p130-E2F4-DP12 Raf1-p130-E2F4-DP12) 0.8)
	(= (duration-synthesis-reaction Raf1-p130-E2F4p1-DP12-gE2 c-Myc) 4.3)
	(= (duration-synthesis-reaction Raf1-p130-E2F4p1-DP12-gE2 cycA) 4.6)
	(= (duration-synthesis-reaction Raf1-p130-E2F4p1-DP12-gE2 cycD) 3.8)
	(= (duration-synthesis-reaction Raf1-p130-E2F4p1-DP12-gE2 cycDp1) 4.3)
	(= (duration-synthesis-reaction Raf1-p130-E2F4p1-DP12-gE2 cycE) 3.8)
	(= (duration-synthesis-reaction Raf1-p130-E2F4p1-DP12-gE2 cycEp1) 3.5)
	(= (duration-synthesis-reaction Raf1-p130-E2F4p1-DP12-gE2 p107) 3.3)
	(= (duration-synthesis-reaction Raf1-p130-E2F4p1-DP12-gE2 p107p1) 3.9)
	(= (duration-synthesis-reaction Raf1-p130-E2F4p1-DP12-gE2 p19ARF) 4.5)
	(= (duration-synthesis-reaction Raf1-p130-E2F4p1-DP12-gE2 pol) 4.4)
	(= (duration-association-reaction Raf1-p130-E2F4p1-DP12 gE2 Raf1-p130-E2F4p1-DP12-gE2) 1.1)
	(= (duration-association-reaction Raf1 p130-E2F4p1-DP12 Raf1-p130-E2F4p1-DP12) 1.0)
	(= (duration-synthesis-reaction Raf1-p130-E2F5-DP12-gE2 c-Myc) 3.9)
	(= (duration-synthesis-reaction Raf1-p130-E2F5-DP12-gE2 cycA) 4.5)
	(= (duration-synthesis-reaction Raf1-p130-E2F5-DP12-gE2 cycD) 3.4)
	(= (duration-synthesis-reaction Raf1-p130-E2F5-DP12-gE2 cycDp1) 3.9)
	(= (duration-synthesis-reaction Raf1-p130-E2F5-DP12-gE2 cycE) 4.0)
	(= (duration-synthesis-reaction Raf1-p130-E2F5-DP12-gE2 cycEp1) 3.2)
	(= (duration-synthesis-reaction Raf1-p130-E2F5-DP12-gE2 p107) 4.5)
	(= (duration-synthesis-reaction Raf1-p130-E2F5-DP12-gE2 p107p1) 3.9)
	(= (duration-synthesis-reaction Raf1-p130-E2F5-DP12-gE2 p19ARF) 3.7)
	(= (duration-synthesis-reaction Raf1-p130-E2F5-DP12-gE2 pol) 3.3)
	(= (duration-association-reaction Raf1-p130-E2F5-DP12 gE2 Raf1-p130-E2F5-DP12-gE2) 1.1)
	(= (duration-association-reaction Raf1 p130-E2F5-DP12 Raf1-p130-E2F5-DP12) 0.8)
	(= (duration-synthesis-reaction Raf1-p130-E2F5p1-DP12-gE2 c-Myc) 4.1)
	(= (duration-synthesis-reaction Raf1-p130-E2F5p1-DP12-gE2 cycA) 4.0)
	(= (duration-synthesis-reaction Raf1-p130-E2F5p1-DP12-gE2 cycD) 3.7)
	(= (duration-synthesis-reaction Raf1-p130-E2F5p1-DP12-gE2 cycDp1) 4.0)
	(= (duration-synthesis-reaction Raf1-p130-E2F5p1-DP12-gE2 cycE) 3.3)
	(= (duration-synthesis-reaction Raf1-p130-E2F5p1-DP12-gE2 cycEp1) 3.5)
	(= (duration-synthesis-reaction Raf1-p130-E2F5p1-DP12-gE2 p107) 4.1)
	(= (duration-synthesis-reaction Raf1-p130-E2F5p1-DP12-gE2 p107p1) 4.4)
	(= (duration-synthesis-reaction Raf1-p130-E2F5p1-DP12-gE2 p19ARF) 4.2)
	(= (duration-synthesis-reaction Raf1-p130-E2F5p1-DP12-gE2 pol) 4.0)
	(= (duration-association-reaction Raf1-p130-E2F5p1-DP12 gE2 Raf1-p130-E2F5p1-DP12-gE2) 0.8)
	(= (duration-association-reaction Raf1 p130-E2F5p1-DP12 Raf1-p130-E2F5p1-DP12) 0.8)
	(= (duration-synthesis-reaction Raf1-pRb-E2F4p1-DP12-gE2 c-Myc) 4.3)
	(= (duration-synthesis-reaction Raf1-pRb-E2F4p1-DP12-gE2 cycA) 3.5)
	(= (duration-synthesis-reaction Raf1-pRb-E2F4p1-DP12-gE2 cycD) 3.3)
	(= (duration-synthesis-reaction Raf1-pRb-E2F4p1-DP12-gE2 cycDp1) 3.5)
	(= (duration-synthesis-reaction Raf1-pRb-E2F4p1-DP12-gE2 cycE) 3.9)
	(= (duration-synthesis-reaction Raf1-pRb-E2F4p1-DP12-gE2 cycEp1) 4.3)
	(= (duration-synthesis-reaction Raf1-pRb-E2F4p1-DP12-gE2 p107) 4.4)
	(= (duration-synthesis-reaction Raf1-pRb-E2F4p1-DP12-gE2 p107p1) 3.9)
	(= (duration-synthesis-reaction Raf1-pRb-E2F4p1-DP12-gE2 p19ARF) 4.2)
	(= (duration-synthesis-reaction Raf1-pRb-E2F4p1-DP12-gE2 pol) 3.3)
	(= (duration-association-reaction Raf1-pRb-E2F4p1-DP12 gE2 Raf1-pRb-E2F4p1-DP12-gE2) 1.1)
	(= (duration-association-reaction Raf1 pRb-E2F4p1-DP12 Raf1-pRb-E2F4p1-DP12) 1.1)
	(= (duration-synthesis-reaction Raf1-pRbp1-E2F4p1-DP12-gE2 c-Myc) 4.0)
	(= (duration-synthesis-reaction Raf1-pRbp1-E2F4p1-DP12-gE2 cycA) 4.5)
	(= (duration-synthesis-reaction Raf1-pRbp1-E2F4p1-DP12-gE2 cycD) 4.2)
	(= (duration-synthesis-reaction Raf1-pRbp1-E2F4p1-DP12-gE2 cycDp1) 3.8)
	(= (duration-synthesis-reaction Raf1-pRbp1-E2F4p1-DP12-gE2 cycE) 3.2)
	(= (duration-synthesis-reaction Raf1-pRbp1-E2F4p1-DP12-gE2 cycEp1) 3.9)
	(= (duration-synthesis-reaction Raf1-pRbp1-E2F4p1-DP12-gE2 p107) 3.8)
	(= (duration-synthesis-reaction Raf1-pRbp1-E2F4p1-DP12-gE2 p107p1) 3.4)
	(= (duration-synthesis-reaction Raf1-pRbp1-E2F4p1-DP12-gE2 p19ARF) 3.3)
	(= (duration-synthesis-reaction Raf1-pRbp1-E2F4p1-DP12-gE2 pol) 4.3)
	(= (duration-association-reaction Raf1-pRbp1-E2F4p1-DP12 gE2 Raf1-pRbp1-E2F4p1-DP12-gE2) 1.1)
	(= (duration-association-reaction Raf1 pRbp1-E2F4p1-DP12 Raf1-pRbp1-E2F4p1-DP12) 1.0)
	(= (duration-association-reaction RPA cycA RPA-cycA) 0.8)
	(= (duration-association-reaction Skp2 cdk2-cycA Skp2-cdk2-cycA) 0.9)
	(= (duration-association-reaction Skp2 cdk2p1-cycA Skp2-cdk2p1-cycA) 1.1)
	(= (duration-association-reaction Skp2-Skp1 cdk2-cycA Skp2-Skp1-cdk2-cycA) 1.0)
	(= (duration-association-reaction Skp2-Skp1 cdk2p1-cycA Skp2-Skp1-cdk2p1-cycA) 0.9)
	(= (duration-association-reaction Skp2 Skp1 Skp2-Skp1) 1.1)
	(= (duration-association-reaction SP1 E2F13 SP1-E2F13) 0.9)
	(= (duration-association-reaction SP1 p107p1 SP1-p107p1) 0.9)
	(= (duration-association-reaction SP1 p107 SP1-p107) 0.9))

(:goal
	(and
	(preference p0A (>= (+ (available p57p1-cdk46-cycD) (available p57p1-cdk46-cycDp1)) 4))
	(preference p0B (>= (+ (available p27-cdk46-cycD) (available cycA)) 4))
	(preference p0C (>= (+ (available p57-cdk46-cycD) (available p57-cdk46-cycDp1)) 3))
	(preference p0D (>= (+ (available HDAC1-p107-E2F4-DP12-gE2) (available c-Myc)) 5))
	(preference p0E (>= (+ (available p57-cdk2-cycE) (available p27-cdk46-cycDp1)) 5))
	(preference p0F (>= (+ (available p27-cdk2-cycE) (available p27-cdk2-cycA)) 3))
	(preference p0G (>= (+ (available p27-cdk2-cycEp1) (available cdk2-cycA-E2F13)) 6))
	(preference p0H (>= (+ (available HDAC1-p130-E2F5-DP12) (available cdk46-cycD)) 7))
	(preference p0I (>= (+ (available cdk2-cycEp1) (available cdk46)) 5))
	(preference p0J (>= (+ (available cdk2-cycE) (available Raf1-cdc25Ap1)) 7))
	(preference p0K (>= (+ (available pol) (available cdk2-cycA)) 4))
	(preference p0L (>= (+ (available Raf1-cdc25A) (available Skp2-cdk2-cycA)) 5))
	(preference p0M (>= (+ (available p57-cdk2-cycEp1) (available cdc25Ap1)) 6))
	(preference p0N (>= (+ (available p57-cdk2-cycA) (available cdk2p1-cycA-E2F13)) 4))))


(:constraints (and

	(preference p1A (sometime-before (> (available p27-cdk46-cycD) 0) (> (available E2F4-DP12) 0)))
	(preference p1B (sometime-before (> (available HDAC1-p107-E2F4-DP12-gE2) 0) (> (available HDAC1-p107-E2F4-DP12) 0)))
	(preference p1C (sometime-before (> (available cdk2-cycA-E2F13) 0) (> (available cycA) 0)))
	(preference p1D (sometime-before (> (available pol) 0) (> (available Raf1-pRb-E2F4p1-DP12-gE2) 0)))
	(preference p1E (sometime-before (> (available cdk2p1-cycA-E2F13) 0) (> (available cdk2p1-cycA) 0)))

	(preference p1F (always (= (available E2F4-DP12-gE2) 0)))
	(preference p1G (always (= (available cdk46) 0)))
	(preference p1H (always (= (available cdc25Ap1) 0)))
	(preference p1I (always (= (available p130-E2F5-DP12) 0)))
	(preference p1J (always (= (available c-Myc-Max) 0)))
	(preference p1K (always (= (available cdc25A) 0)))
	(preference p1L (always (= (available Raf1-p130-E2F5-DP12) 0)))

	(preference p1M (sometime (> (available Raf1-pRbp1-E2F4p1-DP12-gE2) 0)))
	(preference p1N (sometime-after (> (available Raf1-pRbp1-E2F4p1-DP12-gE2) 0) (> (available E2F5-DP12-gE2) 0)))
	(preference p1O (sometime (> (available cdk2p1-cycE) 0)))
	(preference p1P (sometime-after (> (available cdk2p1-cycE) 0) (> (available p57-cdk46p1-cycDp1) 0)))
	(preference p1Q (sometime (> (available DMP1p1-cycDp1) 0)))
	(preference p1R (sometime-after (> (available DMP1p1-cycDp1) 0) (> (available Raf1-p130-E2F4p1-DP12-gE2) 0)))
	(preference p1S (sometime (> (available HDAC1-pRbp1-E2F4-DP12-gE2) 0)))
	(preference p1T (sometime-after (> (available HDAC1-pRbp1-E2F4-DP12-gE2) 0) (> (available DMP1p1-cycD) 0)))
	(preference p1U (sometime (> (available DMP1-cycD) 0)))
	(preference p1V (sometime-after (> (available DMP1-cycD) 0) (> (available cdk2p1-cycEp1) 0)))
	(preference p1W (sometime (> (available Raf1-p130-E2F5p1-DP12) 0)))
	(preference p1X (sometime-after (> (available Raf1-p130-E2F5p1-DP12) 0) (> (available p27-cdk2p1-cycA) 0)))))

(:metric minimize (+ (* 1.8 (is-violated p0A))
		     (* 2.1 (is-violated p0B))
		     (* 2.0 (is-violated p0C))
		     (* 1.8 (is-violated p0D))
		     (* 1.9 (is-violated p0E))
		     (* 2.0 (is-violated p0F))
		     (* 2.0 (is-violated p0G))
		     (* 2.1 (is-violated p0H))
		     (* 2.1 (is-violated p0I))
		     (* 1.9 (is-violated p0J))
		     (* 1.9 (is-violated p0K))
		     (* 2.1 (is-violated p0L))
		     (* 1.9 (is-violated p0M))
		     (* 2.3 (is-violated p0N))
		     (* 1 (is-violated p1A))
		     (* 1 (is-violated p1B))
		     (* 1 (is-violated p1C))
		     (* 1 (is-violated p1D))
		     (* 1 (is-violated p1E))
		     (* 1 (is-violated p1F))
		     (* 1 (is-violated p1G))
		     (* 1 (is-violated p1H))
		     (* 1 (is-violated p1I))
		     (* 1 (is-violated p1J))
		     (* 1 (is-violated p1K))
		     (* 1 (is-violated p1L))
		     (* 1 (is-violated p1M))
		     (* 1 (is-violated p1N))
		     (* 1 (is-violated p1O))
		     (* 1 (is-violated p1P))
		     (* 1 (is-violated p1Q))
		     (* 1 (is-violated p1R))
		     (* 1 (is-violated p1S))
		     (* 1 (is-violated p1T))
		     (* 1 (is-violated p1U))
		     (* 1 (is-violated p1V))
		     (* 1 (is-violated p1W))
		     (* 1 (is-violated p1X))
		     (* 0.01 (total-time))
		     (num-subs)))

)
